The Streptomycetes are gram positive bacteria with a filamentous form that present in a wide variety of soil including composts, water and plants. The most characteristic of Streptomycetes is the ability to produce secondary metabolites such as antibiotics. They produce over two-thirds of the clinically useful antibiotics of natural origin (e.g., neomycin and chloramphenicol. Another characteri...

The aim of this study was to investigate the antimicrobial effect of chitooligosaccharides prepared by chitosanase from Pseudomonas CUY8. Antimicrobial activities of different degrees of deacetylation (DD) and polymerization (DP) of chitooligosaccharides against various species of bacteria and fungi were measured. The antimicrobial effects of chitooligosaccharides compared with chitosan and chi...

INTRODUCTION The increase in emerging human infectious diseases that have a zoonotic origin and the increasing resistance of microorganisms to antimicrobial drugs have shown the need for collaborations between the human, animal and environmental health sectors. The One Health concept increasingly receives recognition from policy makers and researchers all over the world. This overview compiled ...

Recently, antimicrobial peptides have been introduced as potent antibiotics with a wide rangeof antimicrobial activities. They have also exhibited other biological activities, including antiinflammatory,growth stimulating, and anti-cancer activities. In this study, an analog of MagaininII was designed and produced as a recombinant fusion protein. The designed sequence containe...

Antimicrobial peptides are small-molecule proteins that are usually encoded by multiple-gene families. They play crucial roles in the innate immune response, but reports on the functional divergence of antimicrobial peptide gene families are rare. In this study, 14 paralogs of antimicrobial peptides belonging to cecropin, moricin and gloverin families were recombinantly expressed in pET express...

Porcine β defensin 2 (pBD2) is a small, cationic and amphiphilic antimicrobial peptide. It has broad antimicrobial activities against bacteria and plays an important role in host defense. In order to enhance its antimicrobial activity and better understand the effect of positively charged residues on its activity, we substituted eight amino acid residues with arginine or lysine respectively. Al...

Recently, antimicrobial peptides have been introduced as potent antibiotics with a wide rangeof antimicrobial activities. They have also exhibited other biological activities, including antiinflammatory,growth stimulating, and anti-cancer activities. In this study, an analog of MagaininII was designed and produced as a recombinant fusion protein. The designed sequence containe...

Accurate classification of antimicrobial peptides according to their biological activities will facilitate the design of novel antimicrobial agents and the discovery of new therapeutic targets. In this work, an excellent algorithm of Increment of Diversity with Quadratic Discriminant analysis (IDQD) was proposed to classify antimicrobial peptides with diverse biological activities.

recently, the effects of antimicrobial activity of silver nanoparticles was considered by researcher because of bacterial resistance to antimicrobial agents in chemical.the aim of this study was to evaluate the antimicrobial activity of the gold nanoparticles on escherichia coli. gold nanoparticles are chemically synthesized. standard strain of e. coli was cultured in a nutrient broth. minimum ...