Recent developments on antimicrobial quinoline chemistry were shortly reviewed covering six important topics: Historical aspects of the quinoline-based antimicrobial drug development; Increasing resistance problems and reasons for developing new antimicrobial agents; Molecular quinoline-based hybrids in the design and development of novel antimicrobial agents; Structural evolution of the quinol...

In continuation of our endeavor towards the design and development of potent and effective antimicrobial agents, three series of phthalimide derivatives (4a-i, 5a-f, and 6a-c) were synthesized, fully characterized and evaluated for their potential antibacterial, antifungal and antimycobacterial activities. These efforts led to the discovery of nine compounds 4c, 4f, 4g, 4h, 4i, 5c, 5d, 5e, and ...

To develop novel antimycobacterial agents, a new series of thiazolidinone-azole hybrids 4a-b, 5a-b and 6-13 were designed and synthesized. Thiazolidin-4-ones (4a-b and 5a-b) were obtained by the reaction of Schiff bases and hydrazones (2a-b and 3a-b) with mercaptoacetic acid. 5-Benzylidene derivatives (6-13) were gained by treatment of 5a-b with appropriate benzaldehydes according to Knoevenage...

tuberculosis, M. bovis, M. africanum and others, known collectively as the M. tuberculosis complex (MTC) [1]. M. tuberculosis is responsible for more human mortality than any other single microbial species [2]. According to estimates by World Health Organization (WHO), almost 9 million new cases and 1.4 million TB deaths occurred in 2011 [3]. Although there are effective anti-tubercular agents,...

The resurgence of tuberculosis has caused considerable effort to be focused on the development of rapid methods for determining the susceptibility of Mycobacterium tuberculosis to antimycobacterial agents. We demonstrated that susceptibility testing of M. tuberculosis can be accomplished rapidly by using flow cytometry. Results of tests were available within 24 h after M. tuberculosis organisms...

BCG (Bacillus Calmette-Guérin) immunotherapy is a method which an emerging form of cancer treatment. attaches to the bladder wall and stimulates immune response destroy cells. Complications therapy are due reactivated infection or hypersensitivity reaction thus may be treated with antimycobacterial agents, corticosteroids, both. instillations should also stopped if complications occur during tr...

OBJECTIVES The major advantages of Drosophila melanogaster are a well-characterized immune system and high degree of susceptibility to tuberculosis caused by Mycobacterium marinum. The D. melanogaster-M. marinum infection model is gaining momentum as a screening tool because it is genetically amenable, low priced, rapid, technically convenient and ethically acceptable. In this context, the aim ...