نتایج جستجو برای: antitubercular activity

تعداد نتایج: 1136222  

2017
Chunxian He Laura Preiss Bin Wang Lei Fu Hui Wen Xiang Zhang Huaqing Cui Thomas Meier Dali Yin

Bedaquiline (BDQ) is a novel and highly potent last-line antituberculosis drug that was approved by the US FDA in 2013. Owing to its stereo-structural complexity, chemical synthesis and compound optimization are rather difficult and expensive. This study describes the structural simplification of bedaquiline while preserving antitubercular activity. The compound's structure was split into fragm...

Journal: :Bioorganic & medicinal chemistry 2007
Anita Mahapatra Sannah P N Mativandlela B Binneman P B Fourie Chris J Hamilton J J M Meyer F van der Kooy Peter Houghton Namrita Lall

The naphthoquinone 7-methyljuglone (5-hydroxy-7-methyl-1,4-naphthoquinone) has previously been isolated and identified as an active component of root extracts of Euclea natalensis which displays antitubercular activity. Herein, a series of synthetic and plant-derived naphthoquinone derivates of the 7-methyljuglone scaffold have been prepared and evaluated for antibacterial activity against Myco...

Journal: :Journal of the Chilean Chemical Society 2011

Journal: :journal of sciences islamic republic of iran 0

substituted schiff's bases 2a-o prepared by the treatment of 2-amino-4-(?-methoxyiminocarbomethoxymethyl)-thiazole 1 with different aromatic aldehydes, on cyclocondensation with mercaptoaceticacid and mercaptopropionicacid in dry benzene furnished desired thiazolidinones of type 3a-o and 4a-j, respectively. the structure of the compounds have been assigned on the basis of elemental analyse...

2013
Mohammad Asif

There has been considerable interest in the development of new anti tubercular agents particularly against multidrug resistance and extensively drug resistant strain of tuberculosis because mycobacterium species have developed resistant against currently used drugs. The currently use antitubercular drugs having toxic effect and long period of therapeutic treatment. Therefore, many researchers h...

Journal: :Arabian Journal of Chemistry 2021

A series of twenty new chloropyrazine conjugated benzothiazepines (22–41) have been synthesized with 58%–95% yields. The compounds were characterized by using different spectroscopic techniques including FT-IR, 1H NMR, 13C NMR spectroscopy and mass spectrometry. their precursor chalcones (2–21) evaluated for antitubercular cytotoxic activities. Additionally, 22–41 also tested antimicrobial acti...

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