نتایج جستجو برای: antivenom

تعداد نتایج: 906  

Journal: :Critical care and resuscitation : journal of the Australasian Academy of Critical Care Medicine 2002
D C Simes

Two cases of brown snake envenomation are presented where the duration of bandage application in one patient was prolonged compared with the other patient and was associated with a reduction in the total amount of antivenom required. One patient had the bandage removed 2 hours and twenty minutes after application and required 25 units of brown snake antivenom to neutralise the defibrination coa...

2014
Salvatore De-Simone Paloma Napoleão-Pêgo

Background The benefits from treatment with antivenom sera are indubitable. However, the mechanism for toxin neutralization has not been completely elucidated. A mixture of anti-bothropic and anti-crotalic horse antivenom has been reported to be more effective in neutralizing the effects of B. jararacussu snake venom than anti-bothropic antivenom alone. This study determined which regions in th...

Journal: :Hospital pediatrics 2014
Aneesha Narra Erina Lie Matthew Hall Michelle Macy Elizabeth Alpern Samir S Shah Kevin C Osterhoudt Evan Fieldston

BACKGROUND AND OBJECTIVE Treating envenomation with antivenom is costly. Many patients being treated with antivenom are in observation status, a billing designation for patients considered to need care that is less resource-intensive, and less expensive, than inpatient care. Observation status is also associated with lower hospital reimbursements and higher patient cost-sharing. The goal of thi...

2015
Geoffrey K. Isbister Kalana Maduwage Ana Saiao Nicholas A. Buckley Shaluka F. Jayamanne Shahmy Seyed Fahim Mohamed Umesh Chathuranga Alexandre Mendes Chandana Abeysinghe Harindra Karunathilake Indika Gawarammana David G. Lalloo H. Janaka de Silva José María Gutiérrez

BACKGROUND There is limited information on antivenom pharmacokinetics. This study aimed to investigate the pharmacokinetics of an Indian snake antivenom in humans with Russell's viper bites. METHODS/PRINCIPAL FINDINGS Patient data and serial blood samples were collected from patients with Russell's viper (Daboia russelii) envenoming in Sri Lanka. All patients received Indian F(ab')2 snake ant...

2017
Chaturaka Rodrigo Ariaranee Gnanathasan

BACKGROUND Scorpion stings cause an estimated 3000 deaths per annum worldwide. We conducted a systematic review of all controlled clinical trials related to scorpion sting management. METHODS We searched PubMed, EMBASE, Scopus, Web of Science and CINAHL and included controlled prospective clinical trials (randomized or non-randomized). The following interventions were assessed: adults and chi...

2016
Seungho Kang Jeongmi Moon Byeongjo Chun

OBJECTIVE This study aims to help set domestic guidelines for administration of antivenom to envenomated patients after snakebites. METHODS This retrospective observational case series comprised 128 patients with snake envenomation. The patients were divided into two groups according to the need for additional antivenom after the initial treatment based on the traditional snakebite severity g...

2011
H. Asita de Silva Arunasalam Pathmeswaran Channa D. Ranasinha Shaluka Jayamanne Senarath B. Samarakoon Ariyasena Hittharage Ranjith Kalupahana G. Asoka Ratnatilaka Wimalasiri Uluwatthage Jeffrey K. Aronson Jane M. Armitage David G. Lalloo H. Janaka de Silva

BACKGROUND Envenoming from snakebites is most effectively treated by antivenom. However, the antivenom available in South Asian countries commonly causes acute allergic reactions, anaphylactic reactions being particularly serious. We investigated whether adrenaline, promethazine, and hydrocortisone prevent such reactions in secondary referral hospitals in Sri Lanka by conducting a randomised, d...

2002
Offerman Bush SP Moynihan JA Clark RF Hendey GW Wolfson AB Mower WR Hoffman Lubavin BV Langdorf MI Blasko BJ Guldner G Schultz J Sexton P Fortner C Richmond M Guldner GT Babbitt J Boulton M Feleke R Hargrove J Austin T Vilke GM Nyheim E Kelly D Chan TC Green SM Laack TA Hayes WK Cardwell MD Tanen DA Steele R Braun R Grossman SA Van Epp SA Arnold RC Moore RB Lee LC Shapiro NI Parker RA Wolf RE Lipsitz LA. Shneiderman A Christianson J Hardin E Calkins TR Miller K Hill MA Salem L Greenston M Hardin ME Phelps MA Kazzi AA Gee B Kim B Langdorf M

Objective: Pediatric cases comprise approximately 22% of rattlesnake envenomations in the U.S. The recent introduction of Crotaline Fab antivenom and withdrawal from the market of the traditional antivenom preparation has changed the way rattlesnake envenomation is treated. Although in some hospitals Crotaline Fab antivenom may be the only antivenom currently available, there is little data reg...

Journal: :Toxicon : official journal of the International Society on Toxinology 1990
J W Burnett I B Othman R Endean P J Fenner V I Callanan J A Williamson

'Rescue' experiments were performed on mice to compare the efficacy of i.v. verapamil, box-jellyfish antivenom, and a combination of both agents to counter the effects of toxic material extracted from the tentacles of Chironex fleckeri. In each of three series of experiments, four sets of mice were injected with doses of Chironex tentacle extracts containing approximately 4 mg/ml protein which ...

Journal: :Revista de biologia tropical 1988
J M Gutiérrez F Chaves E Rojas J Elizondo C Avila L Cerdas

A monovalent antivenom was produced by immunizing two horses with venom of the pit viper Bothrops asper (Ophidia: Viperidae). Although development of the immune response against four toxic and enzymatic activities of the venom was similar in both horses during the first two thirds of the immunization schedule, antibody response in one of the horses reached much higher levels in the last part of...

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