Alcoholism is characterized by successive periods of abstinence and relapse, resulting from long-lasting changes in various circuits of the central nervous system. Accumulating evidence points to the endocannabinoid system as one of the most relevant biochemical systems mediating alcohol addiction. The endocannabinoid system regulates adult neurogenesis, a form of long-lasting adult plasticity ...

OBJECTIVE: Mobile technology has the potential to radically improve addiction treatment and continuing care by offering emotional and instrumental support anywhere and just in time. This is particularly important in addiction because timing is critical to preventing relapse. Although most experts consider alcoholism to be a chronic disease, providers do not typically offer ongoing support for r...

BACKGROUND & OBJECTIVE Relapse is a common and distressing aspect of substance dependence mediated by several biological and psychosocial factors. This study examined the association between demographic variables, clinical parameters and certain psychosocial factors and relapse among patients with either alcohol or opioid dependence. METHODS Structured assessments of clinical/demographic para...

aim: the purpose of this study was to compare the attention bias about tempting incentives related to opium materials in treated, addicted and normal people. duration of consumption and treating were also considered. method: in this causal-comparative study population was all addicted people who were referred to the rehabilitation offices, addiction treatment clinic, rebirthing centers and narc...

Objectives: In this study, we aimed to determine the individual characteristics of clients who were referred to residential rehabilitation centers for drug use disorders and to determine their relapse-related factors. Methods: This cross-sectional study was conducted on 576 patients who were referred to nine residential treatment centers for drug use disorders, chosen by the cluster sampling m...

BackgroundThere have been few studies on relapse preventive strategies on people with alcohol dependence syndromes. There have been various factors for causes of relapse even after undergoing detoxification and other therapeutic measures. The use of anticraving medications and psychotherapy have been the common modalities used in the management of people dependent on alcohol.. Methods100 cases ...

Background: High prevalence of risky behaviors in alcohol dependents have been shown in several studies, but correlation between alcohol abuse and risky behaviors and relapse in patients with opiate dependence has been less investigated. This study aimed to determine the effect of alcohol abuse in rate of risk-taking behaviors in opiate dependents patients treated on maintenance program in Nort...

BACKGROUND Pavlovian processes are thought to play an important role in the development, maintenance and relapse of alcohol dependence, possibly by influencing and usurping ongoing thought and behavior. The influence of pavlovian stimuli on ongoing behavior is paradigmatically measured by pavlovian-to-instrumental transfer (PIT) tasks. These involve multiple stages and are complex. Whether incr...

Alcohol dependence and dependence on other drugs frequently co-occur, and strong evidence suggests that both disorders are, at least in part, influenced by genetic factors. Indeed, studies using twins suggest that the overlap between dependence on alcohol and on other drugs largely results from shared genetic factors. This common genetic liability, which also extends to antisocial behavior, has...