Aminopeptidase A (APA) cleaves angiotensin (Ang) II, kallidin, and other related peptides. In the brain, it activates the renin angiotensin system and causes hypertension. Limited data are available on the dipsogenic effect of APA and pressor effect of degraded peptides of APA such as bradykinin. Wistar-Kyoto rats received intracerebroventricular (icv) APA in a conscious, unrestrained state aft...

To the Editor: Failure of mouth pressure variations (APm) to reflect alveolar pressure variations (APA) during thoracic gas volume (TGV) measurements by Boyle’s law has been reported in asthmatic patients by Shore and Martin (1) and quite recently by Stanescu et al. (2). In both studies the conclusions were reached by comparing TGV’s obtained by relating plethysmographic volume changes (AVbox) ...

AMA AboShabaan H, Alghannam O, Ismail F, et al. Bone morphogenic protein-7 (BMP-7) polymorphism: Susceptibility to cirrhosis and hepatocellular carcinoma after viral hepatitis in Egyptian patients. Clinical Experimental Hepatology. 2023;9(2):164-171. doi:10.5114/ceh.2023.128616. APA AboShabaan, H., Alghannam, O., Ismail, F., El-Garawani, I., El-Shahat, M., & Talaat, R. (2023). Hepatology, 9(2),...

To the Editor: Failure of mouth pressure variations (APm) to reflect alveolar pressure variations (APA) during thoracic gas volume (TGV) measurements by Boyle’s law has been reported in asthmatic patients by Shore and Martin (1) and quite recently by Stanescu et al. (2). In both studies the conclusions were reached by comparing TGV’s obtained by relating plethysmographic volume changes (AVbox) ...

Recent studies have revealed widespread mRNA alternative polyadenylation (APA) in eukaryotes and its dynamic spatial and temporal regulation. APA not only generates proteomic and functional diversity, but also plays important roles in regulating gene expression. Global deregulation of APA has been demonstrated in a variety of human diseases. Recent exciting advances in the field have been made ...

CONTEXT Antipituitary antibodies (APA) recognizing GH-secreting cells may indicate an autoimmune pituitary involvement in adults with idiopathic GH deficiency (IGHD). OBJECTIVE We aimed 1) to investigate the presence of APA in prepubertal children with IGHD or idiopathic short stature (ISS), identifying the pituitary hormone-producing cells targeted by APA; and 2) to verify whether in patient...

BACKGROUND The AP Advance (APA) is a videolaryngoscope with interchangeable blades: intubators can choose standard Macintosh blades or a difficult-airway blade with increased curvature and a channel to guide the tube to the larynx. The APA may therefore be comparably effective in both normal and difficult airways. We tested the hypotheses that intubation with the APA is no slower than Macintosh...