نتایج جستجو برای: apc

تعداد نتایج: 12498  

Apc

Journal: :Current Biology 2003
Mariann Bienz

How did it get its name? APC is short for adenomatous polyposis coli. The APC gene is mutated in familial adenomatous polyposis, a hereditary form of colon cancer. Carriers of APC mutations develop thousands of colon tumours, some of which inevitably progress to malignancy. Inactivating mutations in APC are also found in the large majority of sporadic colon cancers. APC is therefore an importan...

Journal: :Blood 1991
F España A Gruber M J Heeb S R Hanson L A Harker J H Griffin

In vivo complex formation of activated protein C with protein C inhibitor (APC-PCI) and with alpha 1-antitrypsin (APC-alpha 1AT) following infusion of 0.25 or 1.0 mg APC/kg in 1 hour into baboons was studied using immunoblotting and sandwich enzyme-linked immunosorbent assay (ELISA)s. Before APC infusion, detectable plasma levels (about 30 ng/mL) of APC-alpha 1AT complex were found in the baboo...

Journal: :American journal of physiology. Regulatory, integrative and comparative physiology 2009
Madhuri Bhandaru Daniela S Kempe Anand Rotte Rexhep Rexhepaj Dietmar Kuhl Florian Lang

Adenomatous polyposis coli (APC) fosters degradation of beta-catenin, a multifunctional protein upregulating the serum- and glucocorticoid-inducible kinase (SGK1). SGK1 regulates a wide variety of renal transport processes. The present study explored the possibility that APC influences renal function. To this end, metabolic cage experiments were performed in mice carrying a loss-of-function mut...

Journal: :Turkish journal of clinics and laboratory 2023

Aim: The aim of this study was to evaluate the relationship between atrial premature complexes (APC) and Mediterranean diet score. Rhythm disturbances in heart significantly affect quality life patients. Material Methods: This conducted on 50 patients with palpitations who were referred cardiology outpatient clinic had more than 10000 APC per day as a result 24-hour holter, presented but less 1...

Journal: :Ciencia & Saude Coletiva 2023

Abstract The aim of the present study was to estimate population coverage recording food intake markers in Brazil’s Food and Nutrition Surveillance System (Sisvan) mean annual percent change (APC) according system used for data entry (e-SUS APS Sisvan Web). We conducted an ecological time series period 2015-2019. were stratified into region age group. APC calculated using Prais-Winsten regressi...

Journal: :asia pacific journal of medical toxicology 0
seyed mostafa monzavi addiction research centre, mashhad university of medical sciences, mashhad, iranسازمان اصلی تایید شده: دانشگاه علوم پزشکی مشهد (mashhad university of medical sciences) reza afshari addiction research centre, mashhad university of medical sciences, mashhad, iranسازمان اصلی تایید شده: دانشگاه علوم پزشکی مشهد (mashhad university of medical sciences) nadeem rehman regional coordinator, drug demand reduction and hiv, regional programme for afghanistan and neighbouring countries, unodc

background: in asia pacific (ap) region, the exact picture of the alcohol use problems has remained relatively obscure. in this study, the profile of alcohol consumption and alcohol related disorders in ap countries are presented.     methods: official statistics on average alcohol consumption (alcohol per capita consumption, apc), alcohol related health variables, income group and alcohol poli...

Journal: :IEEE open access journal of power and energy 2021

In regions with high penetration of Distributed Energy Resources (DER), grid congestion is mostly caused by power feed-in generators. this context, conventional approaches for solving the problems are Active Power Curtailment (APC) DER and reinforcement. wake increased generation, it not only interest how to obtain reinforcement, but also consider APC during planning. The challenge such plannin...

Journal: :Proceedings of the National Academy of Sciences of the United States of America 2002
Miwako Kato Homma Dongxia Li Edwin G Krebs Yasuhito Yuasa Yoshimi Homma

Mutations in the adenomatous polyposis coli (APC) gene are responsible for familial adenomatous polyposis coli and also sporadic colorectal cancer development. By using antibodies raised against the N-terminal region of APC protein, we have detected the variable masses of endogenous APC proteins in individual cell lines established from human colorectal carcinomas caused by nonsense mutations o...

Journal: :acta medica iranica 0
sanambar sadighi department of medical oncology, cancer research center, cancer institute of iran, tehran university of medical sciences, tehran, iran. mahsa ghaffari-moghaddam department of medical genetics, cancer research center, cancer institute of iran, tehran university of medical sciences, tehran, iran. mojtaba saffari department of medical genetics, cancer research center, cancer institute of iran, tehran university of medical sciences, tehran, iran. and departement of medical genetics, school of medicine, tehran university of medical genetics, tehran, iran. mohammad ali mohagheghi department of surgical oncology, cancer research center, cancer institute of iran, tehran university of medical sciences, tehran, iran. reza shirkoohi department of medical genetics, cancer research center, cancer institute of iran, tehran university of medical sciences, tehran, iran

desmoids tumors, characterized by monoclonal proliferation of myofibroblasts, could occur in 5-10% of patients with familial adenomatous polyposis (fap) as an extra-colonic manifestation of the disease. fap can develop when there is a germ-line mutation in the adenomatous polyposis coli gene. although mild or attenuated fap may follow mutations in 5΄ extreme of the gene, it is more likely that ...

ژورنال: :پژوهش های آسیب شناسی زیستی 0
nasim vasli department of genetic, school of basic sciences, tarbiat modares university, tehran, iran mehrdad norouzi nia department of genetic, school of basic sciences, tarbiat modares university, tehran, iran aboutaleb sarami women hospital and research center, saram, iran mehrdad azmi cancer research center, tehran university of medical sciences, tehran, iran forouzande mahjoubi national institute genetics engineering biotechnology, tehran, iran

هدف: پولیپوز آدنوماتوز خانوادگی (fap)، نوعی استعداد ارثی به سرطان روده بزرگ با توارث اتوزوم غالب و با نفوذ بالا می باشد. این نشانگان ژنتیکی با حضور بیش از یکصد پولیپ آدنوماتوزی در روده بزرگ و رکتوم شناخته می شود. سایر تظاهرات فنوتیپی شامل تومورهای دسموئیدی، استئوما، تومور در قسمتهای فوقانی دستگاه گوارش و هیپرتروفی مادرزادی پوشش رنگی شبکیه می باشند. ژن apc در اکثر قریب به اتفاق بیماران جهش یافته...

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