The recent identification of a mutation in Foxe3 that causes congenital primary aphakia in humans marks an important milestone. Congenital primary aphakia is a rare developmental disease in which the lens does not form. Previously, Foxe3 had been shown to play a crucial role in vertebrate lens formation and this gene is one of the earliest integrators of several signaling pathways that cooperat...

Phacoemulsification with an intraocular lens implant is a safe and effective means of correction of visual loss from cataract. The high frequency of this procedure world wide means inevitable direct surgical complications will be numerous even though infrequent. The approach to correcting aphakia following complicated cataract surgery is dependent on multiple factors including the degree to whi...

UNLABELLED Abstract PURPOSE We present the clinical, paraclinical and therapeutic features in a patient with secondary congenital aphakia. METHODS A 2-year-old patient, diagnosed with congenital rubella syndrome including sensorineural deafness, congenital heart disease, intellectual disability, microcephaly, microphthalmia, and congenital cataract, presented to our clinic for the surgical ...

PURPOSE To investigate the molecular epidemiological basis for the unusually high incidence of sclerocornea, aphakia, and microphthalmia in a village in the Tlaxcala province of central Mexico. METHODS A population census was performed in a village to identify all sclerocornea, aphakia, and microphthalmia cases. Molecular analysis of the previously identified Forkhead box protein E3 (FOXE3) m...