Apocrine carcinomas represent a rare group of tumors with a potential for destructive local invasion, regional and distant metastases, and are equally common in both sexes. A case of a 79-year-old woman with axillary apocrine carcinoma associated with apocrine adenoma and apocrine gland hyperplasia is presented. To our knowledge, this is the first case diagnosed in a Caucasian and also the firs...

BACKGROUND Apocrine metaplasia is occasionally superimposed on sclerosing adenosis (apocrine adenosis) in breast biopsies, and cytologic atypia is sometimes present (atypical apocrine adenosis). The long term risk of patients developing breast carcinoma subsequent to the diagnosis of this lesion is unknown. METHODS Atypical apocrine adenosis was defined as apocrine adenosis with enlarged nucl...

Apocrine carcinoma of the breast is a rare, special type of breast carcinoma showing distinct morphologic, immunohistochemical and molecular genetic features. Apocrine epithelium has a characteristic steroid receptor profile that is estrogen receptor and progesterone receptor negative and androgen receptor positive. This combination of morphologic and immunohistochemical characteristics is esse...

Apocrine hidrocystomas (cystadenomas) are cystic cutaneous neoplasms derived from apocrine sweat glands (1, 2), and they most often present in adults as solitary (rarely multiple) lesions involving the head, eyelids and neck (3). They are also reported infrequently in the apocrine gland bearing areas like axillae, areola of the nipple, periumbilical, anal, and genital areas (3, 4). We present a...

Introduction: Apocrine carcinoma (AC) is an uncommon variant of breast carcinoma. The incidence of apocrine carcinoma is approximately 4% of mammary carcinomas. Case Series: In this study five cases of apocrine breast carcinoma were identified. Three cases of apocrine breast carcinoma with infiltrating (IF) AC and two cases with intraductal (ID) AC. The cytologic featuers showed large malignant...

Hamartoma is a local malformation resulting from faulty development in an organ. It was first described breast 1971 by Arrigoni et al and its occurrence very rare. This tumor composed of lobules admixed with fibrous tissue fibroadipose tissue. Myoid hamartoma, also called as muscular hamartoma , smooth muscle cells addition to ducts, lobules, stroma. Here, we report case myoid which occurred 53...

Intraductal/intracystic papillary carcinoma (IPC) of the breast is defined as a malignant non-invasive papillary tumor arising from the ductal-lobular system. Based on the presence of myoepithelial cells in the cystic wall, IPC is distinguished from encapsulated papillary carcinoma (EPC). Here, we report a case of an intracystic apocrine papillary tumor in the breast of a 49-year-old woman. His...

Malignant papillary neoplasms of the breast comprise a number of microscopically distinct lesions, where apocrine metaplasia is commonly found in papillomas compared to other papillary lesions including papillary carcinomas. However, association of apocrine metaplasia in papilloma with Ductal Carcinoma in Situ (DCIS) is not very well defined. The lesions with apocrine metaplasia are not only di...

OBJECTIVES To determine the cellular localization in male and female axillary tissue for apocrine secretion odor-binding proteins 1 (ASOB1) and 2 (ASOB2) and the electrophoretic pattern of female apocrine proteins and to begin characterization of the ASOB1 protein. DESIGN Immunohistochemical techniques were used with biopsy samples from axillary tissue of male and female subjects. Immunologic...

Apocrine carcinoma, which is strictly defined as over 90% of tumor cells showing apocrine differentiation, is a rare variant of breast cancer. Here we report an uncommon case in which apocrine carcinomas developed concurrently in both breasts; in addition, a sarcomatoid spindle cell lesion was coincident in the right breast. Both apocrine carcinomas were immunohistochemically negative for estro...