Analytical isoelectric focusing (IEF) has been applied to the study of the apolipoprotein components of rat serum high density and very low density lipoproteins. The apolipoproteins were separated on 7.5% polyacrylamide gels containing 6.8% urea, with a pH gradient of 4-6. The middle molecular weight range apolipoproteins were identified on IEF gels by the use of apolipoproteins purified by ele...

background apo-lipoprotein e (apoe) and carnitine palmitoyltransferase1-a (cpt1-a) genes are well known to be involved in the pathophysiology of psychiatric disorders such as schizophrenia but regarding their cpg island methylation status data is sparse. objectives the aims of the current study were to highlight the effect of the promoter “hypermethylation” in the development of scz. patients a...

Glycated hemoglobin (HbA1c) is used to assess glycemic control in Type 1 diabetes (DM1) patients. Apolipoproteins play an essential role DM1 pathophysiology and may be associated with complications HbA1c. This cross-sectional observational study of 81 children adolescents both sexes diagnosed investigated the relationship between body fat distribution lean mass HbA1C apolipoprotein values, anal...

Micellar, discoidal complexes of human apolipoproteins A-I, A-II, C-I, C-II, C-III-1, and C-III-2 with egg phosphatidylcholine (egg-PC) and cholesterol were prepared by the cholate dialysis method. The complexes, isolated by gel filtration, had similar lipid and protein contents by weight, on the average: 1.77:0.083:1.0, egg-PC/cholesterol/apolipoprotein (w/w). The diameters of the discs, visua...

The apolipoproteins of trout plasma lipoproteins have been characterized by sodium dodecyl sulfateglycerol polyacrylamide gel electrophoresis. The high density lipoproteins (HDL) (1.085 < d < 1.21 g/ml) contain four apolipoproteins, two major species with M, 25,000 (apoA-I-like) and M, 13,000 (apoA-11-like) and two minor species (M, 55,000 and 40,500). The very low density (d < 1.015 g/ml) and ...

Studies on the association between lipid profile and venous thromboembolism (VTE) are inconsistent. This could be caused by classical lipoproteins being inferior to apolipoproteins as markers for VTE risk. Therefore, we examined whether apolipoproteins are more strongly related to VTE than lipoproteins. For this analysis we used the PREVEND prospective community based observational cohort study...

The C apolipoproteins are normally transferred to high density llpoprotelns (HDL) after lipolysis of very low density llpoproteln (VLDL) trlglycerlde. In previous studies, a loss of plasma C apolipoproteins was documented after heparin-induced lipolysis In hypertriglyceridemic subjects. The present studies were designed to determine If this decline In plasma C apolipoproteins was due to their c...

Apolipoprotein B (ApoB) and ApoE have been shown to participate in the particle formation and the tissue tropism of hepatitis C virus (HCV), but their precise roles remain uncertain. Here we show that amphipathic α-helices in the apolipoproteins participate in the HCV particle formation by using zinc finger nucleases-mediated apolipoprotein B (ApoB) and/or ApoE gene knockout Huh7 cells. Althoug...

Amphipathic α-helices of exchangeable apolipoproteins have shown to play crucial roles in the formation of infectious hepatitis C virus (HCV) particles through the interaction with viral particles. Among the Flaviviridae members, pestivirus and flavivirus possess a viral structural protein Erns or a non-structural protein 1 (NS1) as secretory glycoproteins, respectively, while Hepacivirus inclu...

Introduction Nasal mucus is the first line defense barrier against various allergens. Proteins are functional molecules in mucus and have different roles especially in immune response. Apolipoproteins are plasma proteins that are mainly involved in lipid metabolism, but also have anti-inflammatory properties. The role of this study was to identify apolipoproteins in nasal mucus of allergic rhin...