25-Dihydrosaframycin A(AR1) and 21-decyano-25-dihydrosaframycin A(AR3) were produced by the microbial conversion of saframycin A(SA). Efficient conversion of SA to AR, and AR3 was observed with Rhodococcus amidophifus IFM 144. Though the antimicrobial activity of AR, was one tenth that of SA, the in vitro antitumor activity of AR1 was found to be equivalent to that of SA. In contrast, AR, was b...

This study presents developing procedures and verification of a new hybrid model, namely wavelet packet-genetic programming (WPGP) for short-term meteorological drought forecast. To this end, the multi-temporal standardized precipitation evapotranspiration index (SPEI) has been used as quantifying parameter at two stations Ankara province, Turkey. The WPGP model comprises main steps. In first s...

Objective: To develop a novel software method (AR2) for reducing muscle contamination of ictal scalp electroencephalogram (EEG), and validate this method on the basis of its performance in comparison to a commercially available software method (AR1) to accurately depict seizure-onset location. Methods: A blinded investigation used 23 EEG recordings of seizures from 8 patients. Each recording wa...

Five gram-positive bacterial strains were selected for absorption studies of human serum samples. Strain AR1 (group A, M-type 1) and G148 (group G), with strong immunoglobulin G (IgG) binding capacities, and strain AW43 (group A, M-type 60), binding both IgA1 and IgA2, were compared with Staphylococcus aureus Cowan I and with Staphylococcus epidermidis L603. Both AR1 and G148 were capable of co...

While scientists generally generate new projections with the newest models, paper suggested use of past as a different approach which could be explored and then complement classical approaches. With idea that today is yesterday’s future, set Intergovernmental Panel on Climate Change (IPCC) climate (first-AR1, second-AR2 third-AR3 assessment reports) were compared to gauge-based observations las...

The effects of angiotensin-converting enzyme inhibitor (CEI) SQ14225 on infarct size and regional myocardial blood flow were studied in 21 anesthetized dogs subjected to 6 hours of coronary occlusion. An area of myocardium at risk of necrosis was determined in vivo after 15 minutes of coronary occlusion but before CEI treatment (AR1) using an autoradiographic technique and after treatment after...

The grating thickness limit lFP between the Raman–Nath and the Bragg diffraction regimes is calculated for an index grating placed in an asymmetric Fabry–Perot resonator with a totally reflecting back mirror and compared with that which was obtained for the same grating with no cavity lM . Owing to the increase of the effective interaction length inside the Fabry–Perot cavity, the stronger the ...

P2X receptors are ATP-gated ion channels involved in many physiological functions, and determination of ATP-recognition (AR) of P2X receptors will promote the development of new therapeutic agents for pain, inflammation, bladder dysfunction and osteoporosis. Recent crystal structures of the zebrafish P2X4 (zfP2X4) receptor reveal a large ATP-binding pocket (ABP) located at the subunit interface...