Inorganic trivalent arsenicals are vicinal thiol-reacting agents, and dithiothreitol (DTT) is a well-known dithiol agent. Interestingly, both decreasing and increasing effects of DTT on arsenic trioxide-induced apoptosis have been reported. We now provide data to show that, at high concentrations, DTT, dimercaptosuccinic acid (DMSA), and dimercaptopropanesulfonic acid (DMPS) decreased arsenic t...

The SGVs and the additional advice found here should be used only in conjunction with the introductory guide to the series entitled Using Soil Guideline Values (Environment Agency, 2009a), the framework documents Updated technical background to the CLEA model (Environment Agency, 2009b) and Human health toxicological assessment of contaminants in soil (Environment Agency, 2009c), and Contaminan...

In addition to naturally occurring arsenic, man-made arsenic-based compounds are other sources of arsenic exposure. In 2013, our group identified 12 suspected arsenicosis patients in a household (32 living members). Of them, eight members were diagnosed with skin cancer. Interestingly, all of these patients had lived in the household prior to 1989. An investigation revealed that approximately 2...

Arsenic is widely distributed in the Earth's crust, which contains ~3.4 ppm arsenic. In nature, arsenic is mostly found in minerals and only to a small extent in its elemental form. Arsenic is mainly obtained as a byproduct of the smelting of copper, lead, cobalt, and gold ores. Arsenic trioxide is the primary form in which arsenic is marketed and consumed. There has been no domestic production...

ARSENIC poisoning in livestock may be caused by arsenic trioxide (white arsenic), paris green, sodium arsenite, and sodium arsenate. Arsenic has been a common cause of accidental and criminal poisoning of animals because it often is used to kill insects, parasites, weeds, and rodents and as a tonic for animals. Arsenic compounds usually are palatable to animals, especially when they are hungry ...

Metal compounds have been associated with male reproductive toxicity in vivo. The aim of the present study was to investigate the in vitro effects of 20 metal compounds using rabbit ejaculated spermatozoa as a study model for spermiotoxicity. Five of the metals tested (arsenic, cadmium, chromium, mercury and vanadium) reduced sperm motility and curvilinear velocity. Ultrastructural analyses rev...

Analytical parameters of hydride generation, trapping, gas chromatography and atomic absorption spectrometry detection in a quartz cell furnace (HG/GC/QFAAS) device have been optimized in order to develop an efficient and sensitive method for arsenic compounds speciation. Good performances were obtained with absolute detection limits in the range of 0.1 – 0.5 ng for arsenite, arsenate, monometh...

Contemporary combined therapies that include the use of all-trans retinoic acid (ATRA) and arsenic compounds have reduced relapse rates from ~50 to <10% in acute promyelocytic leukemia (APL) patients, however relapse treatment remains controversial. Treatment outcomes in relapsed patients with APL previously treated with combined ATRA + arsenic compound therapy were investigated. A retrospectiv...

Arsenic is a naturally occurring element, present in soil, ground water and plants. Regions with high geological occurrence of inorganic arsenic have been identified in particular in Asia and other non-European countries. In Europe, environmental arsenic levels are rather low, with the exception of distinct geological or industrial areas. Arsenic is a metalloid, displaying different valences (-...

Arsenic is present in the environment and has become a worldwide health concern due to its toxicity and carcinogenicity. However, the specific mechanism(s) by which arsenic elicits its toxic effects has yet to be fully elucidated. The transcription factor nuclear factor (erythroid-derived 2)-like 2 (Nrf2) has been recognized as the master regulator of a cellular defense mechanism against toxic ...