A novel class of macrolides, the sanglifehrins, was discovered by screening of actinomycete strains with a cyclophilin-binding assay. The chemical structures and absolute stereochemistries of the sanglifehrins A, B, C and D were determined unambiguously by NMR-techniques and by X-ray crystallography of the complex with cyclophilin A. Sanglifehrin A consists of a 22-membered macrocycle containin...

The project focuses on the effects of visual delay on human controllers of remote artefacts. A review of the current literature has been carried out. A pilot experiment with thirty participants has been completed. The experiment consisted of a remotely controlled, wheeled vehicle being driven along a track towards a target. The vehicle had a video camera mounted on it from which images were sen...

The Linked Data principles for publishing data on the Web enable the distributed evaluation of queries, where data sources are discovered during runtime. Data sources can have associated licenses that restrict allowed usages. Besides restrictions on the access to the data sources, the usage terms can also restrict the usage terms which can be assigned to derived data artefacts, e.g. query resul...

This paper contrasts the approach Thomas Edison used when dealing with his claim to have discovered a new force of nature, etheric force, to the approach he used to create successful inventions. It argues that he failed in this adventure into scientific theory making because an erroneous view of science led him to abandon techniques that made him America's most successful inventor. From this I ...

The Heterodyne Instrument for the Far Infrared (HIFI) on board the Herschel Space Observatory is composed of a set of fourteen double sideband mixers. We discuss the general problem of the sideband ratio (SBR) determination and the impact of an imbalanced sideband ratio on the line calibration in double sideband heterodyne receivers. The HIFI SBR is determined from a combination of data taken d...

Self-cleansing of transition metal nitrides is discovered to take place during ultrahigh vacuum annealing of TiN, NbN, and VN thin films. Native oxide layers from air exposure disappear after isothermal anneal at 1000 °C. Also, for TiN, the Ti 2p and N 1s X-ray photoelectron spectra (XPS) recorded after the anneal are identical to those obtained from insitu grown and analyzed epitaxial TiN(001)...

Non-functional requirements define qualities of the software system that ensure effectiveness while embedding any constraints and restrictions on design. A challenge rises with agile implementation in handling non-function regulated environments. Thus, a practitioner's perceptions method tailoring are described relation to inter-team boundaries non-functional requirements. The research comprise...

Sourced from the Tyrrhenian Islands and exchanged over long distances, obsidian was used widely across prehistoric Western Europe. An core bladelets a newly discovered rockshelter site in south-eastern Spain, however, raised possibility of an unrecognised mainland source obsidian. EDXRF analysis Early Magdalenian finds La Boja links them to 125km south-west. The artefacts were discarded during ...