Recent studies have revealed the role of the pRb family members pRb and p130 in the response to vascular injury. We evaluated the arterial injury response in the absence of p107, a protein that shares a high degree of homology with the injury-controlling p130. Carotid artery ligation and perivascular electric injury of the femoral artery were applied to p107 knockout (p107 -/-) mice, and morpho...

BILATERAL ligation of the internal mammary arteries was proposed by Fieschi as a simple surgical means of treating patients with coronary artery disease. The procedure aims to increase the blood pressure in the pericardiophrenic branches of the internal mammary arteries and, thereby enhancing coronary anastomoses to the myocardium. Observations made on patients have been conflicting,' as have t...

: Hemodynamic changes accompanying the initial breaths at time of birth are especially important for a smooth transition fetal to neonatal circulation. Understanding normal transitional physiology and clinical impact adverse adaptation is delineating pathology so as guide physiologically relevant therapies. Disorders such severe perinatal asphyxia, hemodynamically significant patent ductus arte...

BACKGROUND Pharmacological blockade of beta3-integrins inhibits neointimal lesion formation in nonmouse animal models of arterial injury. In contrast, beta3-integrin-deficient (beta3-/-) mice are not protected from neointimal lesion formation after arterial injury. We investigated this discrepancy in beta3-/- and wild-type (beta3+/+) mice using different models of injury. METHODS AND RESULTS ...

Altered blood pressure and flow impact cardiac function during morphogenesis. How the arterial system supports cardiac morphogenesis after circulatory disruptions is not well characterized. We manipulated arterial flow via left atrial ligation (LAL) or arterial load via right vitelline artery ligation (VAL) in Hamburger-Hamilton (HH) stage 21 chick embryos. Embryos were reincubated for 1 h (HH2...

BACKGROUND Epistaxis is a common otolaryngology emergency and is often controlled with first-line interventions such as cautery, hemostatic agents, or anterior nasal packing. A subset of patients will continue to bleed and require more aggressive therapy. METHODS Intractable spontaneous epistaxis was traditionally managed with posterior nasal packing and prolonged hospital admission. In an ef...

Background—Pharmacological blockade of 3-integrins inhibits neointimal lesion formation in nonmouse animal models of arterial injury. In contrast, 3-integrin–deficient ( 3 / ) mice are not protected from neointimal lesion formation after arterial injury. We investigated this discrepancy in 3 / and wild-type ( 3 / ) mice using different models of injury. Methods and Results—After disruption of t...

OBJECTIVE To document the development of aortic regurgitation following occlusion of a patent arterial duct. DESIGN Case series involving nine children referred for surgical ligation of an isolated patent arterial duct. SETTING Academic referral centre. METHODS A preoperative transthoracic and transoesophageal echocardiogram was performed in theatre to look for aortic regurgitation. There...

Treatment of bleeding psedoaneurysms and pseudocysts of the pancreas is controversial. Surgical treatment with pancreatic resection or trancystic arterial ligation is not always satisfactory since postoperative mortality rate is high, especially for lesions located in the pancreatic head and rebleeding is not unusual. Two patients with bleeding pseudoaneurysms (one post traumatic, one spontaneo...