The present study evaluates the adjuvant effect of rec-B2L protein orf virus and widely used oil with purified inactivated FMDV 146S trivalent antigens (O, A Asia 1) in guinea pig model. Rec-B2L expressed prokaryotic expression system was co-administered intradermally antigens. serum antibody titre, CMI response protective efficacy against FMDV-type ‘O’ virulent challenge were assessed. titres ...

Foot-and-mouth disease virus (FMDV) causes vesicular disease of cloven-hoofed animals, with severe agricultural and economic losses. Here we present study using a sublingual (SL) route with the killed serotype Asia 1 FMDV vaccine. Guinea pigs were vaccinated using a commercially available vaccine formulation at the manufacturer's recommended full, 1/4, and 1/16 antigen doses. Animals were chall...

The study investigated the effects of FMD vaccination on acute phase response and milk composition in HF crossbred cows (n = 12) using a cross-over experimental design. In trial 1, one group 6) received inactivated trivalent oil-adjuvanted vaccine [day post-vaccination, (dpv) 0], while mock-vaccinated saline 6). After cooling period 15 days, was repeated by swapping groups. body temperature, dr...

Three serotypes of foot-and-mouth disease virus (FMDV) including A, Asia1 and O, have been detected in Iran. Following the mass vaccination program which was implemented in all parts of the country in 2002, the number of outbreaks has been significantly reduced. Therefore, rapid detection of FMDV and its serotypes in clinical samples is essential for control of new outbreaks. In this study a re...

Foot-and –Mouth disease virus (FMDV) is a positive sense RNA virus and the genome codes for single polyprotein. The FMDV L protein is located at the N terminus of the polyprotein and is the first gene product released from the nascent polyprotein. The leader L protease which is involved in pathogenesis has two known functions: (i) auto-catalytic removal from the N terminus of the viral polyprot...