Neuronal members of the degenerin/epithelial Na(+) channel (DEG/ENaC) family of cation channels include the mammalian brain Na(+) channel 1 (BNC1), acid-sensing ion channel (ASIC) and dorsal-root acid-sensing ion channel (DRASIC). Their response to acidic pH, their sequence similarity to nematode proteins involved in mechanotransduction and their modulation by neuropeptides suggest that they ma...

This contribution describes our efforts in the design of a 130nm CMOS ASIC that implements Skein, BLAKE, JH, Grøstl, and Keccak, the five candidates selected by NIST in the third round SHA-3 competition. The objective of the ASIC is to accurately measure the performance and power dissipation of each candidate when implemented as an ASIC. The design of this ASIC, and its optimization for benchma...

Many central neurons possess large acid-activated currents, yet their molecular identity is unknown. We found that eliminating the acid sensing ion channel (ASIC) abolished H(+)-gated currents in hippocampal neurons. Neuronal H(+)-gated currents and transient acidification are proposed to play a role in synaptic transmission. Investigating this possibility, we found ASIC in hippocampus, in syna...

A library strategy has been developed to enable IBM Microelectronics ASIC development to keep pace with rapid technology enhancements and to offer leadingedge performance to ASIC customers. Library elements are designed using migratable design rules to allow designs to be reused in future advanced technologies; and library contents, design methodology, test methodology, and packaging offerings ...

When there are many people who don't need to expect something more than the benefits to take, we will suggest you to have willing to reach all benefits. Be sure and surely do to take this closing the gap between asic and custom tools and techniques for high performance asic design author david chinnery jun 2002 that gives the best reasons to read. When you really need to get the reason why, thi...

We contrasted the physiology and peripheral targets of subclassified nociceptive and nonnociceptive afferents that express acid-sensing ion channel (ASIC)-like currents. The threshold for current activation was similar in eight distinct cell subclasses regardless of functional modality (pH 6.8). When potency was determined from concentration-response curves, nonnociceptors exhibited currents wi...

High-speed DSP systems are increasingly being implemented on FPGA hardware platforms. This trend is being fuelled by insurmountable ASIC project costs and the flexibility and reconfigurability advantages of FPGAs over traditional DSPs and ASICs, respectively. Very recently, Structured ASIC technology has yielded lower cost solutions to full custom ASIC by predefining several layers of silicon f...

Acid sensing ion channels (ASICs) are proton-gated cation channels that are expressed in the nervous system and play an important role in fear learning and memory. The function of ASICs in the pituitary, an endocrine gland that contributes to emotions, is unknown. We sought to investigate which ASIC subunits were present in the pituitary and found mRNA expression for all ASIC isoforms, includin...

The epithelial sodium (Na ) channel (ENaC) plays a critical role in blood pressure regulation by controlling renal salt and water reabsorption. Channel overactivity can lead to severe hypertension and underactivity to salt wasting and hypotension.1 In addition to their role in salt/water homeostasis, recent studies suggest that ENaC proteins, and their relatives, the acid-sensing ion channel (A...

The ATLAS experiment will replace the present small wheel (SW) detector with a new (NSW) aiming to improve performance of muon triggering and precision tracking in endcap region at high-luminosity LHC. small-strip thin gap chamber (sTGC) is one two technologies used this upgrade. A few custom-designed ASICs are needed for sTGC detector. An ASIC interface board designed test ASIC-to-ASIC communi...