Isavuconazole (BAL4815) is a promising novel broad-spectrum triazole in late-stage clinical development that has proven active in vitro against Aspergillus and Candida species. We compared the in vitro activities of this agent with those of voriconazole and fluconazole by the CLSI (formerly NCCLS) M38-A and M27-A2 procedures against a large collection of 1,007 relevant opportunistic fungi colle...

In this study, twelve fungal lipase producing strains belonging to Aspergillus, Penicillium, Trichoderma and Mucor genera were isolated from palm oil mill effluent composts. The Aspergillus spp. were more frequent (42%) and was present in all the samples assayed. Mucor sp. was the least encountered (8.3%).The lipase producing profile showed that Trichoderma (8.07-8.24 u/mL) and Aspergillus (6.2...

background aflatoxin b1 (afb1) is a highly toxic and hepatocarcinogenic metabolite produced by aspergillus species. some natural products are known to kill fungi and destroy toxins and toxin-producing agents. objectives the purpose of this study is to provide experimental data on the antifungal activity of cumin oils and their components that could be considered suitable for application in food...

Background: Several health problems may be occurred due to consumption of mycotoxin-contaminated foods and feeds. The maize and oilseeds, as the main components of poultry feeds are susceptible to mould contamination and mycotoxin production. The aim of this study was to determine the presence of toxigenic Aspergillus spp. in poultry feeds from Ilaro, Nigeria. Methods: A total of 60 poultry fe...

Fungal growth in damp or water-damaged buildings worldwide is an increasing problem, which has adverse effects on both the occupants and the buildings. Air sampling alone in moldy buildings does not reveal the full diversity of fungal species growing on building materials. One aim of this study was to estimate the qualitative and quantitative diversity of fungi growing on damp or water-damaged ...

We performed Etest and broth microdilution (BMD) susceptibility testing of caspofungin, micafungin and anidulafungin against 67 clinical isolates of Aspergillus spp. and 10 Fusarium spp. Minimal effective concentrations (MECs) by BMD were read after 24 h of incubation at 35 degrees C and Etest MICs were read at 24 and 48 h. MECs < or =0.25 mg/l were obtained with caspofungin for all Aspergillus...

The MICs of amphotericin B and itraconazole for 230 isolates of Aspergillus spp., comprising 156 Aspergillus fumigatus, 20 Aspergillus terreus, 22 Aspergillus flavus, 17 Aspergillus nidulans and 15 Aspergillus niger, were determined by a broth microdilution method with RPMI 1640 medium. No isolate was detected with an MIC of amphotericin B >2 mg/L. Itraconazole MICs >16 mg/L were detected for f...

INTRODUCTION Our aims were to assess risk factors, clinical features, management and outcomes in critically ill patients in whom Aspergillus spp. were isolated from respiratory secretions, using a database from a study designed to assess fungal infections. METHODS A multicentre prospective study was conducted over a 9-month period in 73 intensive care units (ICUs) and included patients with a...

BACKGROUND Information on the role of fungi in non-cystic fibrosis (CF) bronchiectasis is lacking. OBJECTIVES Our aim was to determine the prevalence of and factors associated with the isolation and persistence of fungi from sputum in these patients. METHODS We performed a multicenter observational study comprising adult patients with non-CF bronchiectasis. Persistence of Aspergillus spp. a...

Introduction: Nutritional requirements of fungi are essential for their successful growth in laboratories. Some fungi feed on the compounds present in the insects' bodies. The aim of this study was to evaluate the effect of insects' body powder (IBP) as a supplement for the fungi growth in culture media. Methods: We used 10 mg of IBP, obtained from Anopheles superpictus and Culex theileri mosqu...