background and objectives: datura innoxiamilleris one of the two species of datura (solanaceae) which grow in iran. there are many reports of the biological activities of datura and in the present study the ability of datura innoxia for inhibiting angiogenesis was evaluated. methods: the methanol extract and petroleum ether, chloroform and methanol fractions of datura innoxia flowers were obtai...

prostate cancer is a devastating disease for which current therapies are inadequate. various lines of evidences have suggested the 5-lipoxygenase (5-lox) pathway and the leukotriene receptor pathway are potential targets for prevention or treatment of prostate cancer. thus, search for new anti-cancer drugs targeting 5-lox and leukotriene is very essential and important. the objective of the pre...

ezetimide belongs to a class of lipid lowering compounds that selectively inhibits intestinal absorption of cholesterol and related phytosterols. the purpose of this study is to establish a reliable and quick method for the assignment of ezetimibe in tablets form by high performance liquid chromatography with ultraviolet detection (hplc-uv). a rapid and sensitive hplc method has been developed ...

tolterodine tartrate, is a new, potent and competitive muscarinic receptor antagonist in clinical development for the treatment of urge incontinence and other symptoms of unstable bladder. the purpose of this study is to establish a reliable and quick method for the assignment of tolterodine tartrate by high performance liquid chromatography with ultraviolet detection (hplc-uv). a rapid and sen...

glutathione s-transferases (gsts) are widespread in fasciola. hepatica parasite and sheep liver tissue. study of gsts inhibition assays in f. hepatica and sheep liver tissue are a priority of chemotherapeutic targets in parasitic liver diseases including human fascioliasis in iran. in this research, the whole extract of f. hepatica and sheep liver tissues were purified and eluted for sodium dod...

serum ferritin (sf) levels in 734 seven-year-old children was measured by a radioimmuno assay method, and its possible relation-ship with hemoglobin, hematocrit and mchc was investigated. the results showed there was positive correlation between sf with hemo-globin, hematocrit and mchc values.

proteases play a key role in protein digestion in ticks and other haematophagous insects. our understanding of blood meal digestion in digestive system of ticks can be very useful for better understanding of basic rules for control of ticks. cells of the midgut endocytose blood components. blood proteins uptake by midgut cells, suggesting the presence of proteases in the midgut cells. in this s...

many biological factors affect radiosensitivity. in this study, radiosensitivity among the different blood groups was investigated. peripheral blood sample of 95 healthy people were divided into two parts. one part was irradiated with 2 gy co-60 gamma rays and the second one was considered as control. then all the samples were studied by cytokinesis-blocked micronucleus assay (cbmn assay). our ...

cancer is a major cause of death worldwide and causes serious problems in human life. it is developed by uncontrolled growth of a cell or a group of cells. there are many difficulties in treatment of cancer and many researchers are involved in investigating for effective drugs to treat the disease. caryophyllaceae is a large family of about 86 genera and 2200 herbaceous or subshrub species. the...

background and objective: gastric cancer is the fourth common and the second deadliest cancer worldwide, which the major causes of its prevalence are genetic factors and the lifestyle, such as eating fast foods, physical inactivity, environmental pollution, and other natural factors. method: this research was performed in human and animal cell bank of iranian biological resource center, and cyt...