G protein-coupled receptors (GPCRs) constitute a large family of receptor proteins that sense molecular signals on the exterior of a cell and activate signal transduction pathways within the cell. Modeling how an agonist activates such a receptor is fundamental for an understanding of a wide variety of physiological processes and it is of tremendous value for pharmacology and drug design. Inela...

The treatment of [1,1-(PR3 )2 -3-(Py)-closo-1,2-RhSB9 H8 ] (PR3 =PMe3 (2) or PPh3 and PMe3 (3); Py=pyridine) with triflic acid (TfOH) affords [1,3-μ-(H)-1,1-(PR3 )2 -3-(Py)-1,2-RhSB9 H8 ](+) (PR3 =PMe3 (4) or PMe3 and PPh3 (5)). These products result from the protonation of the 11-vertex closo-cages along the Rh(1)B(3) edge. These unusual cationic rhodathiaboranes are stable in solution and in...

To describe a successful pregnancy and delivery after calcium ionophore oocyte activation in a normozoospermic patient with previous repeated failed fertilization after intracytoplasmic sperm injection (ICSI).Case report. In vitro fertilization unit in a university affiliated medical center.A couple with 5 years of unexplained primary infertility who had repeated failed fertilization after ICSI...

The mechanism of C-H activation at metathesis-relevant ruthenium(II) benzylidene complexes was studied both experimentally and computationally. Synthesis of a ruthenium dicarboxylate at a low temperature allowed for direct observation of the C-H activation step, independent of the initial anionic ligand-exchange reactions. A first-order reaction supports an intramolecular concerted metalation-d...

The reaction mechanism of Pd2+-catalyzed regioselective C–H alkylation indole with MesICH2CF3OTf has been investigated by the density functional theory calculations. mainly contains four steps: activation, oxidative addition, reductive elimination, and ligands substitution. From our calculations, we find that activation step was realized acetate anion (−OAc) assisted concerted metalation deprot...