background sarcoidosis is a multisystem granulomatous disorder of unknown etiology, characterized by “noncaseating granulomas” in different organs. clinical signs are variable and dependent on the organ involved. although it is often asymptomatic in athletes, considering the high level of athletic performance and the related risks due to the potential heart involvement, a particular diagnostic ...

The syndrome variously called Da Costa's syndrome, effort syndrome, neurocirculatory asthenia, etc has been studied for more than 100 years by many distinguished physicians. Originally identified in men in wartime, it has been widely recognised as a common chronic condition in both sexes in civilian life. Although the symptoms may seem to appear after infections and various physical and psychol...

Asthenia is a non-specific syndrome common in general practice and occurs patients with acute chronic somatic disorders, including infectious ones. The novel coronavirus infection (COVID-19) one of the leading causes severe persistent asthenia. hypothalamicpituitary- adrenal axis essential for development asthenia since its dysfunction provoked by various factors (including infections) results ...

Asthenia senile syndrome is coded R54 in the International Classification of Diseases (ICD-10). Today, prevalence this among elderly people worldwide 13%, while "senile preadjustment syndrome" 50%. With an unfavourable course, without early treatment and rehabilitation, prehospital develops into asthenia after 4-5 years. This a key concept modern gerontology.

We describe the electrocardiographic changes during everyday activities recorded by ambulatory electrocardiographic monitoring in 67 patients with neurocirculatory asthenia. The findings were compared with the results of ambulatory monitoring in 33 healthy controls. We observed episodes of sinus tachycardia > 120/min unrelated to effort in 60 of the patients, 35 had frequent episodes of pronoun...

Cardiotoxicity has been extensively reported in venlafaxine (VEN) overdoses. Asthenia is also among the common side effects described for this antidepressant. VEN is metabolized mainly by CYP2D6 and to a minor extent by CYP2C19 to the major active metabolite O-desmethylvenlafaxine (ODV). Altered pharmacokinetic parameters in patients with polymorphisms in the CYP2D6 and CYP2C19 genes that resul...

The profi le of primary hyperparathyroidism (PHPT) changed profoundly over the course of the twentieth century. The highly symptomatic forms reported in the 1960s have progressively been replaced by forms with few symptoms and in some cases totally asymptomatic forms. As of 1991, with the increasing frequency of these new forms, several consensus meetings designed to defi ne the criteria for es...