The paper Js the second part of a 2-part paper The first part focused on the ~ssues of data structure and fast difference operation_ The second studies the nonconvergence of the alternating sum of volumes (ASV) process. An ASV ~s a series of convex components fomed by alternating umon and d~fference operattons It ~s desJrable that an ASV series be finite However, such ~s not always the case the...

Background: Nocturnal adaptive servoventilation (ASV) therapy is now frequently used to treat Cheyne-Stokes respiration (CSR), which is highly prevalent in patients with moderate-to-severe heart failure (HF) and characterized by periodical breathing (hyperventilation). Objectives: This study analyzed and compared the acute effects of a novel ASV device on carbon dioxide pressure (pCO 2 ) and ox...

Effect of vibration-induced white finger (VWF) on the hearing was examined in 289 Japanese forest workers. From 51 subjects suffering from VWF and 228 with no history of VWF, 37 pairs were formed, matched for age and hours of noise exposure. The cases with VWF had a significantly higher hearing threshold at 4 and 8 kHz than their matched controls. This result was corroborated by the follow-up s...

Targeting neuropeptide systems is important for future advancements in treatment of neurological and psychiatric illnesses. However, many of the peptides and their analogs do not cross the blood-brain barrier (BBB) efficiently. Nanoparticles such as iron oxide can cross the BBB, and here we describe a novel method for the conjugation of a peptide antisauvagine-30 (ASV-30) to iron oxide nanopart...

Adaptive servo-ventilation (ASV) has been attracting attention as a novel respiratory support therapy for heart failure (HF). However, the acute hemodynamic effects have not been compared between ASV and continuous positive airway pressure (CPAP) in HF patients.We studied 12 consecutive patients with stable chronic HF. Hemodynamic measurement was performed by right heart catheterization before ...

Central Sleep Apnoea (CSA) occurs commonly in heart failure. Adaptive servo-ventilation (ASV) and deadspace (DS) have been shown in research settings to reverse CSA. The likely mechanism for this is the increase of PaCO(2) above the apnoeic threshold. However the role of increasing FiCO(2) on arousability remains unclear. To compare the effects of ASV and DS on sleep and breathing, in particula...

BACKGROUND & OBJECTIVES The optimal anti-snake venom (ASV) dose required to treat neurotoxic snake envenomation is not known. Low-dose ASV (national protocol: maximum dose 200 ml) may be as efficacious as the conventional regimen (100 ml six hourly till all symptoms disappear), but a direct comparison of the regimens is not available. The aim of this study was to test the efficacy of low-dose A...

BACKGROUND Sleep apnea is common in hospitalized heart failure (HF) patients and is associated with increased morbidity and mortality. OBJECTIVES The CAT-HF (Cardiovascular Improvements With MV-ASV Therapy in Heart Failure) trial investigated whether minute ventilation (MV) adaptive servo-ventilation (ASV) improved cardiovascular outcomes in hospitalized HF patients with moderate-to-severe sl...

Sleep-disordered breathing (SDB) has a close relation to heart failure (HF), the incidence of fatal cardiovascular events, and mortality.1 Adaptive servo-ventilation (ASV) therapy has been shown to be effective for central sleep apnea (CSA) and Cheyne–Stokes respiration (CSR).2,3 Recently, ASV therapy has also been used to treat patients with HF who also have CSA and CSR2,4,5 as well as patient...

BACKGROUND Long-term adaptive servoventilation (ASV) increases cardiac function more effectively than continuous positive airway pressure (CPAP), possibly via alleviation of sympathetic overactivation. The present study evaluated the effect of ASV and CPAP at comparable pressure on muscle sympathetic nerve activity (MSNA) in patients with heart failure (HF) and with or without periodic breathin...