An approach to the deformable registration of three-dimensional brain tumor images to a normal brain atlas is presented. The approach involves the integration of three components: a biomechanical model of tumor mass-effect, a statistical approach to estimate the model's parameters, and a deformable image registration method. Statistical properties of the sought deformation map from the atlas to...

While modern imaging technologies such as fMRI have opened exciting possibilities for studying the brain in vivo, histological sections remain the best way to study brain anatomy at the level of neurons. The procedure for building histological atlas changed little since 1909 and identifying brain regions is a still a labor intensive process performed only by experienced neuroanatomists. Existin...

The purpose of this paper is to extend the single-subject Eve atlas from Johns Hopkins University, which currently contains diffusion tensor and T1-weighted anatomical maps, by including contrast based on quantitative susceptibility mapping. The new atlas combines a "deep gray matter parcellation map" (DGMPM) derived from a single-subject quantitative susceptibility map with the previously esta...

For non-compact manifolds with boundary we prove that bounded geometry defined by coordinate-free curvature bounds is equivalent to bounded geometry defined using bounds on the metric tensor in geodesic coordinates. We produce a nice atlas with subordinate partition of unity on manifolds with boundary of bounded geometry, and we study the change of geodesic coordinate maps.

There is a tendency toward the creation of thematic maps on the web in the ongoing development of cartographic technology. However, automatically creating maps through the web and creating interactive web maps are two challenges associated with this field. To solve these problems, a web thematic cartography method based on a web service chain is presented here. Automated cartography is performe...

Diabetic macular edema (DME) is characterized by hard exudates. In this article, we propose a novel statistical atlas based method for segmentation of such exudates. Any test fundus image is first warped on the atlas co-ordinate and then a distance map is obtained with the mean atlas image. This leaves behind the candidate lesions. Post-processing schemes are introduced for final segmentation o...

The increasing availability of geospatial datasets, software, and analysis tools has resulted in the expanded use of maps in the field of public health. Web-based mapping has the potential to greatly enhance the accessibility of these maps and other public health data to health practitioners and the general public. Framework of Web Atlas (FWA) is a novel framework for building web atlas applica...

The Allen Mouse Brain Connectivity Atlas is a three-dimensional, high-resolution map of neural connections in the mouse brain. Axonal projections from a broad range of brain regions were mapped on a standardized platform to generate a comprehensive database of neural projections. Built upon an array of transgenic mice genetically engineered to target specific cell types, the Allen Mouse Brain C...

elling across a country for the first time, a single roadThe availability of complete genome sequences for humap is usually sufficient to find the way. However for man and other organisms is expected to change the more sophisticated expeditions, additional maps are way we formulate and address biological questions. needed. Wine connoisseurs searching for new vintages With nearly all genes in ha...