OBJECTIVE This study aimed to compute phase synchronization of the alpha band from a multichannel electroencephalogram (EEG) recorded under repetitive flash stimulation from migraine patients without aura. This allowed examination of ongoing EEG activity during visual stimulation in the pain-free phase of migraine. METHODS Flash stimuli at frequencies of 3, 6, 9, 12, 15, 18, 21, 24, and 27 Hz...

BACKGROUND The overexpression of Aurora A kinase (AurA) has been reported in various malignancies, including acute myeloid leukemia (AML). However, the expression of AurA and the effects of AurA inhibition in cancer stem cells are not yet fully understood. We investigated the expression and inhibition of AurA in AML stem cells (CD34(+)/CD38(-)). METHODS Expression of AurA was investigated in ...

Heart rate changes are common in epileptic and non-epileptic seizures. Previous studies have not adequately assessed the contribution of motor activity on these changes nor have evaluated them during prolonged monitoring. We retrospectively evaluated 143 seizures and auras from 76 patients admitted for video EEG monitoring. The events were classified according to the degree of ictal motor activ...

BACKGROUND The aim of this study was to determine the plasma levels of cyclooxygenase-2 (COX-2) and visfatin in different stages and different subtypes of migraine headaches compared to a control group to elucidate the pathological mechanisms involved. MATERIAL AND METHODS We recruited a case-control cohort of 182 adult migraine patients and 80 age-matched and gender-matched healthy controls. T...

Timely activation of Aurora kinase A (AURA, also known as AURKA) is vital for centrosome formation and the progression of mitosis. Nonetheless, it is still unclear if and when other cellular functions are activated by AURA. We report here that Src phosphorylates and activates AURA at T288, and AURA also activates focal adhesion kinase (FAK, also known as PTK2), leading to initiation of cell mov...

the following attempts to discuss the different approaches to privacy adopted by adolf loos and le corbusier, as two of the most influential pioneers of modern architecture. it will be argued that both architects were influenced by the developing technologies of their time, yet they reacted differently to the increasing influence of film and photography on art, architecture and everyday life. t...

This review describes the subjective experience of visual aura in migraine, outlines theoretical models this phenomenon, and explores how these may be linked to neurochemical, electrophysiological, psychophysical differences sensory processing that have been reported migraine with aura. Reaction–diffusion used model hallucinations thought arise from cortical spreading depolarisation depression ...

INTRODUCTION Persistent migraine aura without headache is an extremely rare condition. The International Headache Society defines various subtypes of migraines, including "persistent migraine aura without infarction" and "typical aura without headache." CASE PRESENTATION We describe the case of a 21-year-old Asian woman with a history of migraine without aura who had (as her first aura episod...

OBJECTIVES The aim of this study was to assess the prevalence of right-to-left (R to L) shunt in patients with visual aura and evaluate the effect of shunt closure on resolution of aura. BACKGROUND Right-to-left shunting is associated with migraine headache (MH) with aura. Some patients present with visual aura without headaches. It is unclear whether visual aura without headache is a form of...