OBJECTIVE To investigate the prevalence of a group of different autoantibodies, in Omani patients with gastric cancer, and to examine whether their presence correlates with clinical course of the disease. METHODS Ninety-three Omani patients with gastric cancer, and 100 gender-matched blood donors were investigated for the presence of 15 different auto-antibodies against nuclear antigens (ANA)...

The regulation of immune mechanisms is controlled by major histocompatibility complex/human leukocyte antigen (MHC/HLA). Polymorphisms the HLA region have an impact on susceptibility to complex infectious and autoimmune diseases. present study was carried out determine frequencies ASMA, AMA, ANA, dsDNA, anti-LKM-1 auto-antibodies in hepatitis C patients their association with DRβ1 (*04) locus. ...

The aetiology of ulcerative colitis is unknown but an underlying immunological disturbance has frequently been implicated. This might be due to an autoimmune reaction (Broberger and Perlmann, 1959, 1962, 1963; Wright, 1964) or to reactions to an exogenous antigen (Andresen, 1925, 1942; Truelove, 1961; Wright, 1964). We have published our studies on the possible role of dietary allergy elsewhere...

This report examines the use of 5-(and-6)-carboxyfluorescein diacetate succinimidyl ester (CFSE) to determine the site, duration and cell type responsible for antigen presentation in vivo. Evidence that CFSE-labelled T cells can be used to determine where various types of antigens are presented, including auto-antigens, oral antigens and cell-associated foreign antigens, is provided. Using this...

Detailed analysis shows that current high levels of car-use are not an inevitable consequence of the physical, cultural or social structure of Australasian cities (Mees 2010b). It should be possible to provide high-quality public transport, with correspondingly high ridership and improved economic efficiency. Since at least the early 1980s, various social movements have articulated the limits t...

The total cost of auto theft to the U.S. in 1985 is estimated at $6 billion at current prices, or about $45 per automobile per year. On the basis of this estimate, it is calculated that it would be cost-effective for society to invest a few hundred dollars per car in built-in security to prevent auto theft. In practice, there is very little incentive for individual owners to prevent auto theft,...

When explaining customers that the artificial intelligence approach of our products automatically adapts document classifiers on training documents by applying statistical machine-learning, their reaction is similar like if we would tell them about an artificial intelligence in car breaks. Most likely they would dislike it, because they want full control on their data processors. Hence, we sell...

Pemphigus is an autoimmune disease in which IgG auto-antibodies (auto-ab) against the desmosomal cadherins desmoglein (Dsg) 3 and Dsg1 cause loss of epidermal keratinocyte adhesion. Aim of this study was to investigate cytokines derived from antigen-presenting cells (APC) and their relation to CD4+ T cell subpopulations and to the auto-ab response in pemphigus. In this regard, patients with pem...

T cells have an important role during the development of autoimmune diseases. In adjuvant arthritis, a model for rheumatoid arthritis, we found that the percentage of CD4+ T cells expressing the activation marker CD134 (OX40 antigen) was elevated before disease onset. Moreover, these CD134+ T cells showed a specific proliferative response to the diseaseassociated epitope of mycobacterial heat s...