background there have been very few studies evaluating the close association between excess iron and cirrhosis; however, cirrhosis could be regarded as an iron-loading disorder. objectives in this study, the goal was to show the levels of the iron content in the liver tissue in certain types of cirrhosis. patients and methods in this 7 year study (2008 - 2014), in 1000 explanted livers, the amo...

Parvovirus B19 infection is usually self-limiting in immunocompetent individuals. Twenty-five percent of infected individuals are
 completely asymptomatic during infection, with 50% them presenting flu-like symptoms and the remaining patients presenting
 erythema infectiosum, arthralgia, or arthritis. More rarely, transient aplastic crisis seen chronic haemolytic
 disorders. Chro...

Autoimmune cholangitis (AIC) or autoimmune cholangiopathy is a chronic inflammation of liver and a variant syndrome of autoimmune hepatitis (AIH). We present a case of an adult female who had biochemical features of cholestasis and transaminasemia but aminotransferases were not in the hepatitis range and had histological evidence of bile duct injury which was subsequently diagnosed as autoimmun...

Background Chronic liver diseases (CLD) in children represent a growing health problem with significant morbidity and mortality. This study aimed to define the clinicopathological pattern of pediatric CLD in Sohag University Hospital, Sohag,Upper Egypt. Materials and Methods A total of 151children with CLD were included in a prospective hospital-based study from June 2014 to May 2018. Cases of...

background: creating autoantibodies against thyroid in hepatitis c patients who are being treated with interferon is now recognized for several years. recently, some studies have claimed that prevalence of autoimmune thyroid disorders in hepatitis c patients is higher when they are not treated by interferon and/or at the beginning of diagnosis, however the area still remained controversial. in ...

Type I polyglandular autoimmune syndrome is characterized by the triad of hypoparathyroidism, Addison's disease and chronic mucocutaneous candidiasis. Chronic active hepatitis has been associated with this syndrome but its incidence and severity have not been well documented. We describe a sibship of two patients with type I polyglandular autoimmune syndrome who presented with autoimmune chroni...

autoimmune hepatitis is (aih) is a chronic hepatitis that occurs in children and adults of all ages. it is characterized by immunologic and autoimmune features, including circulating auto antibodies and high serum globulin concentrations. it was first described in the 1950s by term of chronic active hepatitis. it has 2 types with different auto antibodies. diagnosis is based upon serologic and ...

The portal tract mononuclear cell infiltrate has been characterised in 28 liver biopsy samples showing features of chronic aggressive hepatitis from 12 patients with autoimmune chronic active hepatitis, 12 with primary sclerosing cholangitis, and four with other chronic liver diseases (two with alpha 1-antitrypsin deficiency, one with Wilson's disease, and one with chronic hepatitis B infection...

Hepatitis a general term which refers to inflammation of the liver. It may result from various causes, both infectious ( viral, bacterial, fungal, and parasitic) noninfectious (alcohol, drugs, autoimmune diseases, metabolic diseases). The hepatitis B X protein (HBx) plays role in epigenetic regulation HBV replication. Real-time PCR has catalysed wider acceptance because it is more rapid, sensit...

A case is reported of a 29 year old female who had autoimmune hepatitis associated with mixed connective tissue disease (MCTD). The patient developed MCTD at the age of 19, and was treated with prednisolone. Liver dysfunction developed 7 years later, which exacerbated shortly after the patient suffered intrauterine fetal death during the second trimester of pregnancy. Laboratory data showed neg...