We analyze the case of a 49-year-old male patient who presented with clinical signs acute hepatitis an initial suspicion autoimmune etiology. Laboratory findings demonstrated positive antinuclear antibody, anti-smooth muscle antibody and high serum gamma globulin. Histology liver biopsy revealed changes compatible hepatitis, which associated International Autoimmune Hepatitis Group score 7, det...

introduction drug-induced liver injury is a frequent cause of hepatic dysfunction. several drugs have been identified to cause autoimmune hepatitis (aih). environmental chemicals are capable of triggering a certain degree of liver injury. however, toxin induced aih is rare. conclusions chronic (long-term) exposures to dichlorvos can lead to aih. a detailed inquiry of medical history and liver b...

background this prospective study was designed to examine the role of fibrosis staging on selection and success of treatment options for autoimmune hepatitis (aih). materials and methods the project was conducted on 110 selected aih patients who, based on the results of liver biopsy, had been assigned into one of the three groups (mild, stages 1 and 2, moderate, stages 3 and 4, and severe, stag...

conclusions with our laboratory diagnostic method, it seems that there are no cases of oci in patients with aih. however, we recommend further studies with more samples and more precise laboratory method. results six males and 29 females with mean disease duration of 77.1 ± 39.5 month and mean age of 43.62 ± 12.67 years were investigated. all cases were negative for anti-hcv antibody and we cou...

Autoimmune hepatitis is defined as chronic liver disease of unknown aetiology with aberrant auto-reactivity and genetic predisposition, characterized by female predominance, circulating auto-antibodies, hypergammaglobulinemia and association with HLA DR3 and HLA DR4. We present two patients with autoimmune hepatitis. The first patient is a young lady who was diagnosed with autoimmune chronic he...

A case is reported of a 29 year old female who had autoimmune hepatitis associated with mixed connective tissue disease (MCTD). The patient developed MCTD at the age of 19, and was treated with prednisolone. Liver dysfunction developed 7 years later, which exacerbated shortly after the patient suffered intrauterine fetal death during the second trimester of pregnancy. Laboratory data showed neg...

celiac disease has been associated with other autoimmune disorders such as autoimmune hepatitis, moreover it is known that t cell mediated immune response to dietary gluten and released cytokines are important for the entheropathy seen in celiac disease. we investigated celiac autoantibodies in patients with autoimmune hepatitis (aih), and chronic hepatitis b (chb). sera from 84 patients with a...

aim : the aim of this study was to review our experience with gestations in autoimmune hepatitis patients. background : there are only limited data describing pregnancy in patients with autoimmune hepatitis. patients and methods : retrospective analysis of pregnancies with autoimmune hepatitis followed in centro hospitalar do porto, portugal in the last ten years. results : we reported nine pre...

Autoimmune hepatitis also known as Lupoid hepatitis is an autoimmune liver disease characterized by the presence of autoantibodies including antinuclear antibodies (ANA) and hyper gammaglobulinemia. SLE can be associated with hepatitis, which is referred to as lupus hepatitis. It is important to distinguish these two entities, as the course of the disease is different in both. It has also been ...