INTRODUCTION Osteoarthritis (OA) represents an increasing health issue worldwide. Regenerative medicine (RM) has raised the hope for introducing revolutionary therapies in clinical practice. Detection of autologus cell sources can improve accessibility to RM strategies. OBJECTIVES To assess the presence and biological potential of mesehchymal stem cells in three tissues (subchondral bone, syn...

In recent years, asparaginase-based chemotherapy regimens have produced excellent short-term efficacy in patients with extranodal natural killer/T-cell lymphoma (ENKTL). However, few long-term outcomes have been reported to date. A phase II clinical trial evaluating the efficacy and safety of a combination of gemcitabine, oxaliplatin and asparaginase (GELOX), followed by radiotherapy (RT) in th...

Pineoblastomas are rare, malignant, pineal region lesions that account for <0.1% of all intracranial tumors and can metastasize along the neuroaxis. Pineoblastomas are more common in children than in adults and adults account for <10% of patients. The management of pinealoblastoma is multimodality approach, surgery followed with radiation and chemotherapy. In view of aggressive nature few centr...

Osteoid osteoma is a small tumor, always benign. Located preferentially on the long bones, femur and tibia, elbow location is rare. We present a case of an Osteoid osteoma in unusual subperiostal localization in the tip of the coronoid process. The lesion was removed by en bloc resection under CT-guidance. This approach enabled us to avoid damaging the proximal structures, to examine the lesion...

The previous two articles described the use of platelet-rich plasma and platelet lysate. This part literature review examines mechanism red bone marrow action, indications contraindications for its use. results treatment delayed consolidation fractures are also described. Hematopoietic stem cells give rise to all cellular components circulating blood, such as blood cells, lymphocytes, neutrophi...

In recent years, bone tissue regeneration studies have led to a deeper knowledge of chemical and structural features of the best biomaterials to be used as replacements for lost bone structures, with the autologus bone still today the only graft material able to ostegenerate, osteinduct and/or osteoconduct. The difficulties of the small available amount of autologus bone, together with morbidit...

Fourteen face transplants have been performed worldwide since the procedure was successfully introduced in 2005. Vascularized composite tissue allotransplantation may now be considered a viable option for the repair of complex craniofacial defects, for which the results of autologus reconstruction remain suboptimal. However, the benefits must be balanced against the risks inherent in major surg...