Baicalin (BA) is a major constituent of Scutellaria baicalensis Georgi, a medicinal herb. Previous pharmacokinetic studies of BA showed its low oral bioavailability. The aim of the present study was to develop a novel BA-loaded liposome (BA-LP) to enhance oral bioavailability. BA-LP, composed of BA, Tween(®) 80, Phospholipon(®) 90H, and citric acid at weight ratio of 96/50/96/50, respectively, ...

Background. Baicalin (BA) exhibits ill understood neuroprotective, anti-inflammatory, and antioxidative effects in brain injury. Objective. To identify the differential network pathways associated with BA-related biological effects. Methods. MCAO-induced mice received BA 5 mg/Kg (BA group). Controls received vehicle only. Following ischaemia-reperfusion, ArrayTrack analysed the whole genome mic...

Neurointensivist, Neuro/Cardio ICU, Hospital Espanhol, Salvador BA, Brazil; Chief, Neurology Department, Hospital São Rafael, Salvador BA, Brazil; Coordinator, Adult ICU, Hospital Santo Amaro, José Oliveira Foundation, Salvador BA, Brazil; Chief, Neurology Department and Neuro/cardio ICU, Hospital Espanhol, Salvador BA, Brazil; Coordinator, Adult ICU, Hospital da Cidade, Salvador BA, Brazil; Su...

Polycyclic aromatic hydrocarbons (PAHs) are widespread genotoxic environmental pollutants and potentially pose a health risk to humans. Although the biological and toxicological activities, including metabolism, mutagenicity, and carcinogenicity, of PAHs have been thoroughly studied, their phototoxicity and photo-induced biological activity have not been well examined. We have long been interes...

Extruded breakfast cereals (EBC), processed from two oat lines, N979-5-2-4 (N979) and "Jim", with beta-glucan concentrations of 8.7 and 4.9%, respectively, were used to determine the impact of dry solids (DS) and bile acid (BA) concentrations on in vitro BA binding efficiency. A full fractional factorial design with levels for BA concentrations of 0.20, 0.47, 0.95, 2.37, and 4.73 micromol/g of ...

This paper details the comparison of a built coupled volume concert hall and a computergenerated model of the hall. Coupled volume spaces typically have an auxiliary volume connected to the main volume through an acoustically transparent aperture. In this type of space, architectural parameters such as volume size and surface absorption can be designed to produce a non-linear reverberant decay,...

Bile acids (BA) have recently been shown to increase energy expenditure in mice, but this concept has not been tested in humans. Therefore, we investigated the relationship between plasma BA levels and energy expenditure in humans. Type 2 diabetic (T2DM) patients (n = 12) and gender, age and BMI-matched healthy controls (n = 12) were studied before and after 8 weeks of treatment with a BA seque...

Isotopic compos•tien and concentration of barium in six stone meteorites and the silicate inclusions of two iron meteorites and three terrestrial samples were measured by use of a 'double spike' isotopic dilution technique in order to correct for laboratory fractionation. Any differences between the abundances of the isotopes in meteoritic and terrestrial Ba were found to be less than 0.1% for ...

The reactivity of metal olefin complexes with non-innocent ligands (NILs) was examined. Treatment of PtCl(2)(diene) with the deprotonated catechol or aminophenol ligands afforded the corresponding Pt(NIL)(diene) complexes. The Pt((t)BA(F)Ph)(COD), Pt((t)BA(F)Ph)(nbd), and Pt(O(2)C(6)H(2)(t)Bu(2))(COD) (H(2)(t)BA(F)Ph = 2-(2-trifluoromethyl)anilino-4,6-di-tert-butylphenol, H(2)O(2)C(6)H(2)(t)Bu(...

Reaction between LiH and the A(n)B(n-1)O(3n) cation deficient perovskite phases Ba(5)Nb(4)O(15), Ba(6)TiNb(4)O(18) and Ba(3)LaNb(3)O(12) proceeds by reductive lithium insertion, leading to the formation of Ba(5)LiNb(4)O(15), Ba(6)LiTiNb(4)O(18) and Ba(3)LaLiNb(3)O(12) respectively. During lithium insertion into Ba(5)Nb(4)O(15) and Ba(6)TiNb(4)O(18) the respective ccchh and cccchh stacking seque...