Bacopa monnieri extract has been implicated in the recovery of memory impairments due to various neurological disorders in animal models and humans. However, the precise molecular mechanism of the role of CDRI-08, a well characterized fraction of Bacopa monnieri extract, in recovery of the diabetes mellitus-induced memory impairments is not known. Here, we demonstrate that DM2 mice treated oral...

Bacopa monnieri is a well known herb for its use in enhancing memory and in treatment of epileptic disorders ever since from ancient times. While effects of hydro-methanolic extracts of Bacopa monnieri on isolated heart has not been reported yet, so in this present study we aim to investigate effect of 75% hydromethanolic extract of Bacopa monnieri on isolated frog heart and cytotoxic activity ...

An efficient micropropagation protocol of Bacopa monnieri (L.) Pennell through two-stage culture nodal segments and ex vitro acclimatizationShashikanta Behera, Nibedita Nayak, Shasmita, Durga P. Barik, Soumendra K. Naik

1. The Indian Herbal Pharmacoepia. Regional Research Laboratory and Indian Drug Manufacturers Association. Mumbai: IDMA; 2002. p. 467. 2. Archana R, Namasivayam A. Antistressor effect of Withania somnifera. J Ethnopharmacol 1999;64:91-3. 3. Jha NK, Jha AK. Bacopa monnieri: Brahmi. Phytopharm 2005;11:3-14. 4. Gupta AP, Mathur S. High performance thin layer chromatography method for determination...

OBJECTIVE The objective of this study was to investigate the effectiveness of Bacopa monnieri Linn. for improvement of memory performance in healthy older persons. STUDY DESIGN This was a randomized, double-blind, placebo-controlled trial. SETTING AND PARTICIPANTS The trial took place in Lismore, NSW, Australia between February and July 2005. Ninety-eight (98) healthy participants over 55 y...

BACKGROUND Bacopa monnieri is a medicinal plant which has long been used in Ayurvedic medicines to augment brain function and to improve memory. The purpose of our study was to identify and evaluate possible toxic effects of B. monnieri extract in rats by assessing hematological, biochemical, and histopathological parameters. METHODS Acute oral toxicity of Bacopa monnieri extract was studied ...

Enhanced production of total saponins was obtained from 40 day old suspension cultures of Bacopa monnieri. The callus yielded not only a 166% increased concentration of saponins but also produced two novel prominent bands of saponins compared to the natural plant system. We report here for the first time an increased potential of cell lines of B. monnieri in suspension for production of saponin...

Immune system plays an important role in pathogenesis of diabetes (DM). Besides hypoglycaemics, rasayanas are indicated in the management of DM. In several studies the immunomodulatroy potentials of rasayanas have been proved. A clinical trial of three rasayana drugs, Asparagus recemosus (AR). Bacopa monnieri (BM) and Centella asiatica (CA) was carried out in diabetics. In this study, diabetics...

Diabetic neuropathic pain is generally considered to be one of the most troublesome complications affecting diabetic patients and current therapy provides inadequate pain relief. In the present study, the neuroprotective effect of Bacopa monnieri, Linn. (Brahmi, BM) targeted at adenosine receptor was studied in a model of diabetic neuropathic pain. Diabetes was induced by streptozotocin (65 mg/...

In an 8-week greenhouse experiment, Bacopa monnieri (water hyssop) and Leersia oryzoides (rice cutgrass) were compared for nutrient assimilation as well as soil and water chemistry under variable flooding regimes using a nutrient solution rich in nitrogen (N) and phosphorus (P). Soil redox potential decreased in flooded treatments; however, mesocosms containing B. monnieri remained aerobic for ...