Gram-negative bacterial endocarditis causes 5% of all bacterial endocarditis. Among gram-negative bacteria, Klebsiella species are rare causes of native valve endocarditis. Klebsiella oxytoca is an extremely rare subspecies that can infrequently cause endocarditis and is associated with poor outcome. We report a case of Klebsiella oxytoca endocarditis in an elderly man who initially presented w...

A patient with bacterial endocarditis had headaches, cerebrospinal fluid pleocytosis and normal cerebral angiograms. Fifteen days later, while on appropriate antibiotic therapy, he developed an intracerebral hematoma due to a mycotic aneurysm. Mycotic aneurysm is an infrequent but serious complication of bacterial endocarditis. An aneurysm should be considered whenever a patient with bacterial ...

Fourteen episodes of subacute bacterial endocarditis in 11 children were successfully treated with antibiotics, which in 13 cases were given largely by mouth. It is suggested that oral treatment of bacterial endocarditis should be considered for children who are only moderately but not severely ill, and who have sensitive organisms.

IN the autumn of 1944 a small committee was formed in Belfast to investigate the clinical applications of penicillin, and for various research projects special supplies of penicillin were received from the Medical Research Council of Great Britain. In February, 1945, the committee agreed to accept responsibility in Northern Ireland for a thorough clinical trial of penicillin in subacute bacteri...

ABBOTT, M. E. Atlas of Congenital Cardiac Disease, New York, 1936. BROWN, J. W.: Congenital Heart Disease, London, 1939. GRANT, R. T.; WOOD, J. E., JUN.; and JONES, T. D.: "Heart-Valve Irregularities in Relation to Subacute Bacterial Endocarditis," Heart, 14, 247, 1928. OKELL, C. C., and ELLIOTT, S. D. : "Bacterieemia and Oral Sepsis, with special reference to wtiology of Subacute Endocarditis,...

It is widely believed that subacute bacterial endocarditis and atrial fibrillation are very rarely found in the same patient. The older reports emphasize this point (Horder, I926; Libman and Friedberg, I94I), and even attach diagnostic significance to it. In view of the changes that have occurred in the picture of endocarditis in the past two to three decades (Anderson and Staffiurth, i955; Hug...

Up to 1945 reports of the treatment of bacterial endocarditis with penicillin were disappointing. Early in that year, however, more encouraging results were obtained with larger doses, and it became urgently necessary to determine the optimum dosage. With this end in view a committee was set up by the Penicillin Clinical Trials Committee with Professor R. V. Christie as secretary and representa...

We present a case of right-sided infective endocarditis due to methicillin-resistant Staphylococcus aureus that occurred in an injectable drug user. Traditionally, cities such as Detroit and San Francisco have been associated with certain bacterial infections. Upon further review, these relationships appear more tenuous and argue that identification to the level of "strain" will be required to ...