BACKGROUND Early recognition is a key factor to achieve improved outcomes for septic patients. Combinations of biomarkers, as opposed to single ones, may improve timely diagnosis and survival. We investigated the performance characteristics of sepsis biomarkers, alone and in combination, for diagnosis of verified bacterial sepsis using Sepsis-2 and Sepsis-3 criteria, respectively. METHODS Pro...

The spectrum of organisms causing sepsis is different in developing countries. Data on the recent trends of organisms causing sepsis are limited. This study was conducted in a tertiary care neonatal unit in Northern India. All inborn babies with blood-culture-positive sepsis from 1995 to 2006 were divided into two epochs, viz. 1995 to 1998 (epoch I) and 2001 to 2006 (epoch II). Organisms were g...

BACKGROUND AND OBJECTIVES Rhabdomyolysis is often associated with sepsis and gram positive bacterial pathogens are reported to be the most frequent cause of sepsis induced rhabdomyolysis. We report the pattern of infecting bacterial pathogens and associated causal factors in a South-Indian cohort. DESIGN, SETTING, PARTICIPANTS #ENTITYSTARTX00026; MEASUREMENTS Retrospective cohort study of adu...

INTRODUCTION This paper investigates the role of Group II Secretory Phospholipase A2 (sPLA2-IIA) as a biomarker for the diagnosis of sepsis and bacterial infection in adults. Sepsis and bacterial infection are common problems encountered by patients in the hospital and often carry adverse outcomes if not managed early. METHODS Two independent reviewers conducted a comprehensive search using O...

Blood culture, the gold standard for diagnosis of neonatal sepsis has low sensitivity and is time consuming. Therefore, objective is development and application of Polymerase chain reaction (PCR)-based DNA sequencing to detect and identify bacterium causing neonatal sepsis in culture negative specimens. Sixty three peripheral blood and 8 cerebrospinal fluid (CSF) referred from tertiary level Ne...

background it is known that risk factors related to neonatal bacterial sepsis are complex. objectives the current study aimed to determine the risk factors of neonatal sepsis. materials and methods this study was conducted on 1023 neonates admitted to neonatal intensive care units (nicus) in south sinai governorate hospitals from january 2010 till september 2014. demographic data of the neonate...

Background Neonatal sepsis is a type of neonatal infection and specifically refers to the presence in a newborn baby of a bacterial blood stream infection (BSI) in the setting of fever. This study aimed to evaluate the prevalence, pathogen distribution, antibiotic resistance pattern and the most common clinical features in infants with suspected sepsis admitted to teaching hospitals of Ilam, Ir...

Transfusion-associated bacterial sepsis (TABS) is caused by bacteria present in blood components. It is one of the earliest recognized adverse transfusion-associated reactions. Blood components most often become contaminated while blood is being collected from a donor; more seldom in the case of asymptomatic bacteremia or erroneous blood processing procedures (1). Although the risk for transfus...

Bacteriology 226 Group B Streptococci 228 Group A Streptococci 229 Streptococcus pneumoniae 231 Other Streptococci 231 Enterococcus species 232 Staphylococcus aureus and Coagulase-Negative Staphylococci 232 Listeria monocytogenes 233 Escherichia coli 233 Klebsiella Species 233 Enterobacter Species 234 Citrobacter Species 234 Serratia marcescens 235 Pseudomonas aeruginosa 235 Salmonella Species ...

During bacterial sepsis, proinflammatory cytokines contribute to multiorgan failure and death in a process regulated in part by cytolytic cell granzymes. When challenged with a sublethal dose of the identified mouse pathogen Brucella microti, wild-type (WT) and granzyme A (gzmA)(-/-) mice eliminate the organism from liver and spleen in 2 or 3 weeks, whereas the bacteria persist in mice lacking ...