The Drosophila germ-cell lineage has emerged as a remarkable system for identifying genes required for changes in cell fate from stem cells into more specialized cells. Previous work indicates that bam expression is necessary for cystoblast differentiation; bam mutant germ cells fail to differentiate, but instead proliferate like stem cells. This paper reports that ectopic expression of bam is ...

Bag of Marbles (Bam) is a stem cell differentiation factor in the Drosophila germ line. Here, we demonstrate that Bam has a crucial function in the lymph gland, the tissue that orchestrates the second phase of Drosophila hematopoiesis. In bam mutant larvae, depletion of hematopoietic progenitors is observed, coupled with prodigious production of differentiated hemocytes. Conversely, forced expr...

Bag of Marbles (Bam) is known to function as a positive regulator of hematopoietic progenitor maintenance in the lymph gland blood cell-forming organ during Drosophila hematopoiesis. Here, we demonstrate a key function for Bam in cells of the lymph gland posterior signaling center (PSC), a cellular domain proven to function as a hematopoietic niche. Bam is expressed in PSC cells, and gene loss-...

The Rsamtools package provides an interface to BAM files. BAM files are produced by samtools and other software, and represent a flexible format for storing ‘short’ reads aligned to reference genomes. BAM files typically contain sequence and base qualities, and alignment coordinates and quality measures. BAM files are appealing for several reasons. The format is flexible enough to represent rea...

BACKGROUND To examine factors predicting type of bladder antimuscarinics (BAM) initiated in nursing home (NH) residents. METHODS Incident BAM initiators following NH admission were identified by constructing a retrospective cohort from Medicare files and Minimum Data Set (MDS). Participants included all residents 65 years and older admitted in Medicare-certified NH between January 1, 2007 and...

The precise mechanisms regulating T-helper function have been intensively investigated. We and others have recently identified a new T-cell-B-cell-activating molecule called T-BAM that directs B-cell differentiation by interacting with the CD40 molecule on B cells. Using a specific monoclonal antibody against T-BAM (5C8), we have previously shown that T-BAM expressing T cells are predominantly ...

2,6-Dichlorobenzamide (BAM), a persistent metabolite from the herbicide 2,6-dichlorobenzonitrile (dichlobenil), is the pesticide residue most frequently detected in Danish groundwater. A BAM-mineralizing bacterial community was enriched from dichlobenil-treated soil sampled from the courtyard of a former plant nursery. A BAM-mineralizing bacterium (designated strain MSH1) was cultivated and ide...

The sex life of Arabs is terra incognita for scientists and policy makers. Shereen El Feki's book "Sex and the Citadel" is the first serious attempt to chart sexual intimacy in the rapidly changing Arab world.

Bandwidth Allocation Models (BAMs) configure and handle resource allocation (bandwidth, LSPs, fibre) in networks in general (IP/MPLS/DS-TE, optical domain, other). BAMs currently available for IP/MPLS/DS-TE networks (MAM, RDM, G-RDM and AllocTC-Sharing) basically define resource restrictions (bandwidth) by “class” (traffic class, application ś class, user ś class or other grouping criteria) and...

Cell differentiation commonly dictates a change in the cell cycle of mitotic daughters. Previous investigations have suggested that the Drosophila bag of marbles (bam) gene is required for the differentiation of germline stem cell daughters (cystoblasts) from the mother stem cells, perhaps by altering the cell cycle. In this paper, we report the preparation of antibodies to the Bam protein and ...