Cocultivation of cellulolytic and saccharolytic microbial populations is a promising strategy to improve bioethanol production from the fermentation of recalcitrant cellulosic materials. Earlier studies have demonstrated the effectiveness of cocultivation in enhancing ethanolic fermentation of cellulose in batch fermentation. To further enhance process efficiency, a semicontinuous cyclic fed-ba...

In this paper optimal control algorithms for two E. coli fed-batch fermentations are developed. Fed-batch fermentation processes of E. coli strain MC4110 and E. coli strain BL21(DE3)pPhyt109 are considered. Simple material balance models are used to describe the E. coli fermentation processes. The optimal feed rate control of a primary metabolite process is studied and a biomass production is u...

Abstract: In this paper an optimal control algorithm for E. coli fed-batch fermentation has been developed. A simple material balance model is used to describe the E. coli fermentation process. The optimal feed rate control of a primary metabolite process is studied and a biomass production is used as an example. An optimization of a fed-batch fermentation process is usually done using the calc...

Cephalosporin C (CPC), a β-lactam antibiotic, is starting molecule for industrial production of semi synthetic cephalosporins. CPC fermentation has been carried out in Air Lift Reactor (indigenously made up of borosilicate glass) in different fermentation modes i.e., batch and fed batch modes using a mold Acremonium chrysogenum (synn. Cephalosporium acremonium). A definite correlation exists be...

Erythromycin production is clearly enhanced by the addition of vegetable oils. However,whether this positive effect is brought about by the triglyceride or non-triglyceride fraction, isnot clear. The non-triglyceride portions of the oils accumulate in the waste during the refiningprocess leaving mainly triglycerides in the refined oil. In this research, sub-fractions of soybeanoil, including le...

erythromycin production is clearly enhanced by the addition of vegetable oils. however,whether this positive effect is brought about by the triglyceride or non-triglyceride fraction, isnot clear. the non-triglyceride portions of the oils accumulate in the waste during the refiningprocess leaving mainly triglycerides in the refined oil. in this research, sub-fractions of soybeanoil, including le...

Continuous fermentation set-ups are of great interest for studying the physiology of microorganisms. In winemaking conditions, yeasts go through a growth phase and a stationary phase during which more than half of the sugar is fermented. A comprehensive study of wine-yeast physiology must therefore include yeasts in a non-growing phase. This condition is impossible to achieve within a chemostat...

Software sensors have attracted great research interests due to the problem of lacking suitable and robust online sensors for key fermentation variables in fed-batch fermentation processes. In this paper, intelligent software sensors have been developed based on multivariate statistical process control methods. The software sensors not only provide real time estimation of key variables but also...

A novel optimal control algorithm is presented for application to batch processes. The algorithm utilises a linear model of the process that is identified using multi-way partial least squares. This linear model is used within an optimal control law to regulate the productivity of the batch by manipulating the substrates that are fed into the fermentation vessel. The proposed control algorithm ...

The review analyses studies on magnetically assisted proliferations and batch fermentations with Saccharomyces cerevisiae yeasts. The results available in the literature are contradictory and show two tendencies: magnetic field suppression of the cell growth and positive effects in batch fermentation with increasing both biomass and metabolite production. The amount of data analyzed allows seve...