With more than 30 years of experimental research, there have been no generic models to classify tumours and identify new types of cancer. Similarly, advances in molecular classification of tumours may play a central role in cancer treatment. Here a new approach to genome expression pattern interpretation is described and applied to the recognition of B-cell malignancies as a test set. Using DNA...

The mechanism of lymphoma genesis in hepatitis C virusrelated, B cell NHL is unknown. It has been suggested that HCV may induce B cell clonal proliferation and BCL-2 gene overexpressionin chronicHCV patients. Aim of the Work: Is to evaluate the expression of BCL2 gene in patients with NHL with HCV infection. Methods: The study included 92 patients, divided into 52 patients with B-cell NHL with ...

firm subcutaneous nodules of between 1 cm and 3 cm in diameter on the trunk and lower limbs (Figure 1), adherent to the deep planes, and with a violaceous contusiform appearance of the overlying skin. Relevant details of the patient ’s history include previous parenteral drug use, hepatitis B virus (HBV) (surface antigen positive), hepatitis C virus (HCV), and HIV (stage B3) infection; she was ...

BACKGROUND Alkaliphilic Bacillus species are intrinsically interesting due to the bioenergetic problems posed by growth at high pH and high salt. Three alkaline cellulases have been cloned, sequenced and expressed from Bacillus cellulosilyticus N-4 (Bcell) making it an excellent target for genomic sequencing and mining of biomass-degrading enzymes. METHODOLOGY/PRINCIPAL FINDINGS The genome of...

Nonmyeloablative allogeneic transplantation (NMAT) infrequently cures active chemoresistant, bulky, or aggressive Bcell lymphoma (B-cell non-Hodgkin lymphoma [B-NHL]). We hypothesized that 90Y-ibritumomab tiuxetan–based NMAT would facilitate early cytoreduction in such patients promoting improved longterm disease control by the allogeneic graft. Forty high-risk B-NHL patients with persistent di...

Non-Hodgkin lymphoma (NHL) is one of the masquerade syndromes of malignant melanoma that can occur with two main patterns of presentations in the eye: metastatic involvement of uveal tract, and primary involvement of retina. We report ophthalmic, imaging and histopathological findings in the first case diagnosed as primary choroidal NHL without central nervous system or systemic involvement. A ...

BACKGROUND primary colorectal lymphoma is a very rare disease, representing less than 0.5 % of all primary colorectal neoplasms. The gastrointestinal tract is the most frequently involved site of all extranodal lymphomas, the most common type of that is non-Hodgkin s lymphoma. Early diagnosis is often difficult because of unspecific symptoms. Therapeutic approaches have classically included rad...

A modification of the double rosette method of Mendes et al. was used to examine lymphoblasts from 22 children with acute lymphoblastic leukemia and 1 child with lymphoblastic lymphoma. This method was used since it directly and simultaneously detected T, B, and null lymphocytes as well as monocytes. In addition it detected the D lymphocyte which has both Tand Bcell surface markers. Based on su...

s: Timar B, Chadburn A, Knowles DM, Cesarman E: The alternative NF-κB pathway is active in the majority of diffuse large B-cell lymphomas. Laboratory Investigation 2006 (86): 248A IF: 3.702 Timar B, Chadburn A, Knowles DM, Cesarman E: Activation of classical and alternative nuclear factor-kappaB (NF-κB) pathways in diffuse large Bcell lymphomas. Blood 104 (11): 12A-13A 29 Part 1 NOV 16 2004 IF:...