Molecular beacons represent a new family of fluorescent probes for nucleic acids, and have found broad applications in recent years due to their unique advantages over traditional probes. Detection of nucleic acids using molecular beacons has been based on hybridization between target molecules and molecular beacons in a 1:1 stoichiometric ratio. The stoichiometric hybridization, however, puts ...

A secondary mutation (T790M) in epidermal growth factor receptor (EGFR) is a hallmark of acquired resistance to EGFR inhibitors used to treat non-small-cell lung cancer (NSCLC). Therefore, identifying the T790M mutation is crucial to guide treatment decisions. Given that DNA sequencing methods are time-consuming and insensitive, we developed and investigated the feasibility of using molecular b...

Stanford's Space Systems Development Laboratory (SSDL) has initiated a new space system technology initiative in order to develop, demonstrate, and validate a beacon monitoring system for spacecraft. This system consists of automated fault detection on board a spacecraft, a state of health beacon signal broadcast by the spacecraft, a ground based monitoring network, and a mission control center...

A methylene-blue (MB)-labeled molecular beacon junction probe allows for a signal-on electrochemical detection of nucleic acids via target recycling using endonucleases. Electron transfer is reduced when the MB is intercalated in the stem of the molecular beacon, but then electron transfer from MB to a gold electrode is enhanced upon cleavage of the junction probe due to increased probability o...

Stanford's Space Systems Development Laboratory (SSDL) has initiated a new space system technology initiative in order to develop, demonstrate, and validate a beacon monitoring system for spacecraft. This system consists of automated fault detection on board a spacecraft, a state of health beacon signal broadcast by the spacecraft, a ground based monitoring network, and a mission control center...

Satellite beacon is a signal which does not modulated and sent to ground in constant frequency with specific designed power. Beacon signals are used by station antenna users track the satellite easily. The operators generally choose at Ku Band band since this more resistant rain attenuation. system performance describe contribute of rainfall rate This paper includes comparison attenuation takin...

Fluorescence detecting of exogenous EpCAM (epithelial cell adhesion molecule) or muc1 (mucin1) expression correlated to cancer metastasis using nanoparticles provides pivotal information on CTC (circulating tumor cell) occurrence in a noninvasive tool. In this study, we study a new skill to detect extracellular EpCAM/muc1 using quantum dot-based aptamer beacon (QD-EpCAM/muc1 ALB (aptamer linker...

In this paper, we develop and evaluate a Localization Anomaly Detection (LAD) scheme for non-flat surfaces for wireless sensor networks. The beacon-less grid localization scheme proposed for non-flat terrains in [1] is used for localization and the localization anomaly detection uses observations of the sensor node at two different reception ranges. Moreover, a new Signal Strength (SS) Metric i...