cancer remains the second leading cause of cancer mortality in the world, although the overall incidence is gradually declining. 1 Gastric cancers can be largely subdivided into early and advanced lesions in nature or intestinal and diffuse type in pathology. Early gastric cancer (EGC) is defined as a cancer that does not invade beyond the submucosa regardless of lymph node involvement, based o...

NuMA is a nuclear matrix protein that has an essential function in the organization of the mitotic spindle. Here we have studied the fate of NuMA in Fas-treated apoptotic Jurkat T and HeLa cells. We show that in both cell lines NuMA is an early target protein for caspases and that NuMA is cleaved coincidently with poly(ADP-ribose) polymerase-1 (PARP-1) and nuclear lamin B. NuMA is cleaved diffe...

The aryl hydrocarbon receptor nuclear translocator (ARNT) is a member of the bHLH PAS (basic helix–loop–helix Period/ ARNT/Single-minded) family of transcription factors. It is the obligatory dimerization partner for many other members of this family, including the aryl hydrocarbon receptor (AHR) and hypoxia-inducible factors 1a and 2a (HIF-1/2a). Agonists for AHR include a variety of environme...

OBJECTIVE The aim of this study was to evaluate tumor characteristics, management and survival in elderly male breast cancer patients in comparison with younger men. METHODS We reviewed medical records of 99 male breast cancer patients between 1972 and 2011. The median age of the patients was 64.5 years. Patient characteristics including clinicopathologic factors, treatment modalities, surviv...

Background: Although the incidence of gastric (adenocarcinoma) cancer has been decreasing over time, it is still one of the most common malignancies worldwide, and proximal tumours tend to have a worse prognosis. Aim: To compare surgical outcomes and prognosis between proximal - excluding tumours of the cardia - and distal gastric cancer. Methods: Out of 293 cases reviewed - 209 with distal...

We are delighted to have the opportunity to respond to the letter by Gilks et al. (Gilks et al., 2017). They argue first that historical pathological entities do not map seamlessly to modern day diagnostic categories, which are not only based on expert review by specialist gynecological pathologists but are also increasingly supported by immunohistochemistry (IHC). Second, that the misclassific...

Recent successes in the crystallographic determination of structures of transmembrane proteins in the G protein-coupled receptor (GPCR) family have established the lipidic cubic phase (LCP) environment as the medium of choice for growing structure-grade crystals by the method termed "in meso". The understanding of in meso crystallogenesis is currently at a descriptive level. To enable an eventu...