Chronic myeloid leukemia chronic phase (CML-CP) CD34(+) cells contain numerous DNA double-strand breaks whose unfaithful repair may contribute to chromosomal instability and disease progression to blast phase (CML-BP). These phenomena are often associated with the appearance of imatinib-resistant BCR-ABL1 kinase mutants (eg, T315I) and overexpression of BCR-ABL1. Here we show that BCR-ABL1 (non...

This study investigates a population decoding paradigm in which the maximum likelihood inference is based on an unfaithful decoding model (UMLI). This is usually the case for neural population decoding because the encoding process of the brain is not exactly known or because a simplified decoding model is preferred for saving computational cost. We consider an unfaithful decoding model that neg...

We analyse the M-theoretic generalisation of the tangent space structure group after reduction of the D = 11 supergravity theory to two space-time dimensions in the context of hidden Kac–Moody symmetries. The action of the resulting infinitedimensional ‘R symmetry’ group K(E9) on certain unfaithful, finite-dimensional spinor representations inherited from K(E10) is studied. We explain in detail...

For the algebra A in the title, its prime, primitive and maximal spectra are classified. The group of automorphisms of A is determined. The simple unfaithful A-modules and the simple weight A-modules are classified.

We study a population decoding paradigm in which the maximum likelihood inference is based on an unfaithful decoding model (UMLI). This is usually the case for neural population decoding because the encoding process of the brain is not exactly known, or because a simplified decoding model is preferred for saving computational cost. We calculate the decoding error of UMLI and show an example of ...