A patient with plasma cell myeloma producing only Bence Jones lambda protein was found to have pale intranuclear inclusions in the majority of the bone marrow plasma cells. These inclusions, previously undescribed in myeloma patients producing only Bence Jones protein, contained Bence Jones lambda protein, were non-electron dense, bound by a single membrane, and contained no cytoplasmic structu...

The primary structure of Bence-Jones proteins is characterized by a variable amino acid sequence in the aminoterminal half and a constant amino acid sequence in the carboxyl-terminal half. Proteins corresponding either to the variant half or to the constant half of whole Bence-Jones proteins have been detected in urine of patients with multiple myeloma. Both halves of a Bence-Jones protein were...

acute plasma cell leukemia with bence-jones proteinuria is reported in a 60 year old lranien male with a 25 day history of acute onset of fever. weakness, weight loss, diarrhea and bloody stools. the patient was noted to be cachectic and anemic. he had purpuric and petechial skin lesions, generalized lymphadenopathy and splenomegaly. up to 80% immature plasma cells were present in the periphera...

Kappa Bence Jones proteinuria was found by immunoelectrophoretic techniques in a patient with plasma cell leukemia, who presented with no M-proteins either in serum or urine. However, a significant decrease in normal immunoglobulins was observed. On microscopic examination of kidney sections obtained a autopsy, protein casts were seen in the distal tubules. Bence Jones protein was not detected ...

Two cases are described which show that on urine protein electrophoresis a paraprotein owing to hemoglobin cannot be distinguished from a Bence Jones protein. A simple method is described for confirming the presence of hemoglobin: a densitometric scan of the electrophoretogram at 415 nm, in which hemoglobin absorbs in a band coincident with the restriction. Furthermore, it is shown that other s...

the presence of decyclase. The biosynthetic demonstration of PCA decylase in a human plasmacytoma producing a Bence Jones protein with a cyclized glutaminyl amino-terminal residue contrasted to the absence of demonstrable decyclase in a murine plasmacytoma, which was also producing a Bence Jones protein with a cyclized glutaminyl amino terminus. These results indicate a lack of correlation betw...