Polycyclic aromatic hydrocarbons (PAHs) and heavy metals are often environmental cocontaminants that could interact to alter PAH carcinogenicity. The heavy metal, arsenite, and the PAH, benzo[k]fluoranthene, were used as prototypes to investigate, in human HepG2 cells, mechanisms whereby the bioactivation of benzo[k]fluoranthene by human CYP1A1 could be diminished by arsenite-mediated decreases...

Airborne fine particulate matter (PM2.5) pollution is known to have adverse effects on human health, and owing their carcinogenic mutagenic nature, polycyclic aromatic hydrocarbons (PAHs) are of particular concern. This study investigated the effect ultraviolet (UV)-induced photocatalysis degradation PAHs in PM2.5, employing titanium dioxide (TiO2)-supporting quartz fibre filters. A TiO2 layer ...

Benzo(a)pyrene 4,5-oxide was rapidly reduced to benzo(a)pyrene by rat liver microsomes in the presence of reduced nicotinamide adenine dinucleotide phosphate when incubated anaerobically. The activity of benzo(a)pyrene 4,5oxide reductase was increased about seven times by pretreat ment of rats with 3-methylcholanthrene. The addition of riboflavin to the incubation mixture resulted in the increa...

The potential effect of asbestos fibers on mutagenicity of benzo(a)pyrene was investigated by using the Ames test. Asbestos fibers without a coating of benzo(a)pyrene or benzo(a)pyrene when not dissolved in DMSO lacked any mutagenic effect in the Salmonella/mammalian microsome mutagenicity test. However, when benzo(a)pyrene was adsorbed onto asbestos, significant numbers of mutated bacteria wer...

Benzo(a)pyrene 4,5-oxide was rapidly reduced to benzo(a)pyrene by rat liver microsomes in the presence of reduced nicotinamide adenine dinucleotide phosphate when incubated anaerobically. The activity of benzo(a)pyrene 4,5oxide reductase was increased about seven times by pretreat ment of rats with 3-methylcholanthrene. The addition of riboflavin to the incubation mixture resulted in the increa...

A method capable of determining 13 PAHs (acenaphthene, anthracene, benzo[a]anthracene, benzo[a]pyrene, benzo[b]fluoranthene, benzo[k]fluoranthene, chrysene, dibenzo[ah]anthracene, fluoranthene, fluorene, indene[1,2,3-cd]pyrene, phenanthrene and pyrene) in a mixture of 16 EPA PAHs by second derivative synchronous spectrofluorometry in the constant wavelength mode was developed. It has not been p...

Benzo[a]pyrene, a ubiquitous environmental pollutant, has been suggested to be capable of initiating and/or accelerating atherosclerosis. Accumulation of vascular smooth muscle cells (VSMCs) in vessel intima is a hallmark of atherosclerosis. Nitric oxide (NO) can suppress VSMCs proliferation and induce VSMCs apoptosis. NO plays a compensatory role in the vascular lesions to reduce proliferation...

vilsmeier-haack reaction of 2,3,3-trimethyl-3h-benzo[g]indole, then aqueous basic work-up, leads to benzo[g]indol-2-ylidene- malondialdehydes. these react with various arylhydrazines and quinolin-2-ylhydrazine to form 3,3-dimethyl-2-(1-aryl-1h-pyrazol-4-yl)- 3h-benzo[g]indoles in good yields.

The possible role of human plasma lipoproteins as car riers in the transport of the carcinogen, benzo(a)pyrene, was assessed in in vitro studies. [14C]Benzo(a)pyrene was incubated in whole human blood, plasma, or isolated lipo protein fractions. Benzo(a)pyrene d istribution between plasma and red blood cells was estimated following sedi mentation of red blood cells. Benzo(a)pyrene distribution ...

A series of benzo[b]furan derivatives having a five-membered heterocyclic substituent at the 2-position were prepared from 2-(1-chloro-2-formylvinyl)benzo[b]furans (2) and 2-(4-alkylcarbamoylbuta-1,3-dienyl)benzo[b]furans. These 2-heterocyclic benzo[b]furans were evaluated for their cysteinyl leukotriene receptor (cysLT1, cysLT2) inhibitory activity. Several compounds showed moderate inhibition...