Four polyphenols were isolated and purified from a brown alga Eisenia arborea. These phlorotannin compounds showed strong radical scavenging some enzyme inhibitory activities. All of the antioxidative, acetylcholinesterase butyrylcholinesterase inhibitory, tyrosinase inhbibitory activities at 100 μg/mL. Dieckol PFF inhibited butyrylcholinesterase, new target for treatment Alzheimer’s disease, v...

A procedure is suggested for measuring acetylcholinesterase and butyrylcholinesterase activities in human whole blood using acetylthiocholine as a substrate and ethopropazine as a selective inhibitor of butyrylcholinesterase. The procedure is suitable for screening cholinesterase activities in routine and/or field tests.

objectives in this study the association of phenotypes and activity of butyrylcholinesterase (buche) with serum level of lipid-lipoprotein and apolipoproteins during various phases of menstrual-cycle was determined. methods the study population consisted of 22 healthy women aged 19–25 years with regular menstrual cycles, 26–30 days in length. the serum levels of lipids, apolipoproteins, and buc...

background: it is becoming apparent that although inhibition of cholinesterase plays a key role in organophosphate (op) toxicity, other factors are also important. one of the contributing factors for severity of op poisoning is electrolyte imbalances such as hypokalemia. this study was aimed at evaluating the value of hypokalemia in association with plasma cholinesterase (pche) levels in predic...

This case is about a 48-year-old woman known with a reduced butyrylcholinesterase activity, who developed prolonged neuromuscular blockade following the unintentional administration of succinylcholine. We took the opportunity to monitor the development of neuromuscular function during this period and blood samples were taken for molecular genetic analysis and for quantitative and qualitative an...

To optimize the expression, extraction and purification of plant-derived tetrameric recombinant human butyrylcholinesterase (prBChE), we describe the development and use of plant viral amplicon-based gene expression system; Tobacco Mosaic Virus (TMV) RNA-based overexpression vector (TRBO) to express enzymatically active FLAG-tagged plant made recombinant butyrylcholinesterase (rBChE) in Nicotia...

INTRODUCTION Risk stratification in patients undergoing extracorporeal membrane oxygenation (ECMO) support after cardiovascular surgery remains challenging, because data on specific outcome predictors are limited. Serum butyrylcholinesterase demonstrated a strong inverse association with all-cause and cardiovascular mortality in non-critically ill patients. We therefore evaluated the predictive...

Acetylcholinesterase (AChE; EC 3.1.1.7) is the primary terminator of nerve impulse transmission at cholinergic synapses and is believed to play an important role in neural development. Targeted deletion of four exons of the ACHE gene reduced AChE activity by half in heterozygous mutant mice and totally eliminated AChE activity in nullizygous animals. Butyrylcholinesterase (EC 3.1.1.8) activity ...