In an attempt to find out a new class of antimicrobial agents new series of Benzylidine-2imino-1,3-benzothiazole and other related products containing benzothiazole moiety were prepared. The synthesis was carried out by condensation of different aromatic aldehydes with benzothiazole derivative using different procedures. The synthesised compounds were characterized and evaluated for antimicrobi...

Schiff base derivatives have recently been shown to possess antimicrobial activity, and these derivatives include a limited number of salicylaldehyde hydrazones. To further explore this structure-activity relationship between salicylaldehyde hydrazones and antifungal activity, we previously synthesized and analyzed a large series of salicylaldehyde and formylpyridinetrione hydrazones for their ...

an environmentally benign and clean synthesis of aryl-hydrazones by reacting variety of carbonyl compounds with thiosemicarbazide, semicarbazide, aminoguanidine, and phenyl hydrazine has been achieved using aqueous extract of acacia concinna pods as a natural surfactant type catalyst. we found that the aqueous extract of acacia concinna pods could be effectively used for the synthesis of aryl-h...

Benzothiazole, the bicyclic ring system consists of thiazole ring fused with benzene ring. The literature study of benzothiazoles reveals that the presence of this bicyclic ring system in various amine or terrestrial natural compounds possess different biological properties. Thus benzothiazole moiety is continuously drawing interest for development of newer drug moiety due to its wide range of ...

A series of some novel 2-amino benzothiazole derivatives were synthesized and evaluated for antiinflammatory activity. The titled compounds were synthesized from the substituted aromatic amines through the intermediate substituted 1-phenylthiourea oxidation by bromine water in acidic medium. The purity of the synthesized compounds were judged by their C, H and N analysis and the structure was a...

Benzotriazole (BTR) and benzothiazole (BTH) derivatives are used in a wide variety of industrial and consumer products and have been reported to occur in the environment. Owing to a lack of analytical methods, human exposure to BTRs and BTHs is still unknown. Therefore, a liquid chromatography-electrospray ionization tandem mass spectrometry (LC–ESI(+)MS/MS) method was developed for simultaneou...

Fragment based Quantitative structure activity relationship (QSAR) analysis on reported 25 2-(2-(4-aryloxybenzylidene) hydrazinyl) benzothiazole dataset as antitubercular agents were carried out. Molecules in the current dataset were fragmented into six fragments (R1, R2, R3, R4, R5, R6).Group based QSAR Models were derived using Multiple linear regression (MLR) analysis and selected on the bas...

The enantioselective addition of anilines to azoalkenes was accomplished through the use of a chiral phosphoric acid catalyst. The resulting α-arylamino hydrazones were obtained in good yields and excellent enantioselectivities and provide access to enantioenriched α-arylamino ketones. A serendipitous kinetic resolution of racemic α-arylamino hydrazones is also described.

Due to its beneficial natural and pharmacological properties, heterocyclic element analogues derivatives have recently received a lot of attention. One the frequently occurring nuclei in both marine grow solutions is benzothiazole. A favoured bicyclist band method with numerous utilizations It well known for exhibiting broad variety activities, including those that are anticancer, antiviral, an...

Rat liver glutamine transaminase acts on y-glutamyl hydrazones of a-keto acids to yield the corresponding L-amino acids and 3-hydroxy-tetrahydro-6-pyridazinone-3-carboxyllc acid; the latter compound undergoes nonenzymatic dehydration in acid to yield 1,4,5,6-tetrahydro-6-pyridazinone -3carboxylic acid. L-Amino acid oxidase (snake venom) also catalyzes the formation of 3-hydroxy-tetrahydro-6-pyr...