the effects of conduction band nonparabolicity, aluminum concentration and external electric field on the charge density and binding energy of an on-center hydrogenic donor impurity in a spherical quantum dot which is located at the center of a cylindrical nano-wire are studied. the energy eigenvalues and the corresponding wave functions are calculated using finite difference approximation with...

zoanthamine-type alkaloids display a wide spectrum of biological effects. this study aimed to examine the inhibitory effects of norzoanthamine and its ten homologues of zoanthamine class on human fibroblast collagenase by modeling a three-dimensional structure of the ligands at collagenase using energy minimization, docking, molecular dynamics simulation and mm-pb/gbsa binding free energy calcu...

Human serum albumin (HSA) is an abundant, multifunctional and nonglycosylated negatively charged plasma protein. HSA ascribed ligand-binding and transport properties, antioxidant functions and enzymatic activities. In the present study, the interaction and side effects of a new designed anti-cancer compound (1,10-phenanthroline butyl dithiocarbamato palladium(II) nitrate) on HSA have been inves...

a thermodynamic study on the interaction between zinc ion (zn2+) and human growth hormone(hgh) was studied at two temperatures of 27c and 37c in aqueous solution using an isothermal titrationcalorimetry. it was found that there is a set of three identical and non-interacting binding sites for zn2+ ions. the intrinsic dissociation equilibrium constant and the molar enthalpy of binding are 1.54...

a thermodynamic study of copper ions by jack bean urease (jbu) was carried out at two temperatures of 27 and 37?c in tris buffer (30 mm; ph=7.0) using an isothermal titration calorimetry. there is a set of twelve identical and non-interacting binding sites for copper ions. the intrinsic dissociation equilibrium constant and the molar enthalpy of binding are 285 µm and ?15.2 kj/mol at 27?c and 3...

a novel ternary schiff base ligand (hl) of ono type and its copper (ii) complex weresynthesised using 2-aminophenol and o-acetoacetotoluidide. they have been characterised by theusual analytical and spectral methods. the interaction of the complex with calf-thymus (ct)dna has been investigated by uv-vis, viscosity measurement, cyclic voltammetry anddifferential pulse voltammetry studies. the re...

Effects of ?-cyclodextrin, ?CD, on refolding of lysozyme was investigated at pH 12 employing isothermal titration calorimetry (ITC) at 300K in 30mM Tris buffer solution. ?CD was employed as an anti-aggregation agent and the heats obtained for lysozyme+?CD interactions are reported and analyzed in terms of the extended solvation model. It was indicated that there are two sets of identical and no...

The extract of licorice (Glycyrrhiza glabra L.) has been widely used for many centuries in the traditional Chinese medicine as native anti-allergic agent. Glycyrrhizin (GL), a triterpenoid-saponin, extracted from the roots of licorice is the most effective compound for inflammation and allergic diseases in human body. The biological and pharmacological studies revealed that GL possesses many ph...