Our group is interested in the intersubunit bridge region of the ribosome, which involves interactions between the 16S and 23S rRNAs. The 16S rRNA makes contacts with 23S rRNA through the A site, which is also an important site for tRNA binding and a known target site for aminoglycoside antibiotics. The 23S rRNA contacts 16S rRNA through helix 69 (H69), which also interacts with the Aand the P-...

Objective(s): Bioactive silicate ceramics have favorable features for applying as off-the-shelf bone and artificial tissue. Calcium silicate can enhance the generation of an immediate bond with host bone without an intervening rough surface in the bone layer. However, the silicate bioceramics have some drawback regarding their mechanical properties and chemical stabilities. Materials and Method...

This brief meeting review summarizes the recommendations of NSF and NPGI funded bioinformaticians concerning the future requirements for plant bioinformatics systems and databases.

We discuss foundational issues of quantum information biology (QIB) – one of the most successful applications of the quantum formalism outside of physics. QIB provides a multi-scale model of information processing in bio-systems: from proteins and cells to cognitive and social systems. This theory has to be sharply distinguished from “traditional quantum biophysics”. The latter is about quantum...

Comprehensive bio-simulation from genes to a body is one of the most important research topics in 21st century. However, no single model or simulator can cover whole-body bio-system. Therefore, it is essential to develop environment for integrating heterogeneous bio-simulators. In this article, three types of key issues for integration of bio-simulators are discussed: (1) a wide variety of scal...

Recently there is a great demand for extending high throughput life science research to biomanufacturing. However, there is a gap from life science research to bio-manufacturing. Most of existing Bio-workflow tools/systems only provide an isolated solution to help bioscientist to orchestrate bio-R&D operations such as bio-database query, bio-computation and analysis etc for specific small bio-p...

 Describe the physical database design process, its objectives, and its deliverables.  Choose storage formats for attributes from a logical data model.  Select an appropriate file organization by balancing various important design factors.  Describe three important types of file organization.  Describe the purpose of indexes and the important considerations in selecting attributes to be in...