extensive breakdown of primary teeth to the cervical level and their loss in very young children is not uncommon. owing to increasing concerns over self-appearance, due considerations to esthetic aspects in addition to restoring function are necessary aspects of rehabilitation of mutilated teeth to help children grow into a psychologically balanced personality. the present article describes reh...

SDZ-ADL is a biosimilar of reference adalimumab. Here, the safety and effectiveness data from British Association Dermatologists Biologic Immuno-modulators Register (BADBIR) are reported. In set, were compared with conventional systemics data. quality-of-life patients treated as first-time biologic, or who switched previous biologic to SDZ-ADL, assessed using Psoriasis Activity Severity Index (...

INTRODUCTION To compare biologic disease-modifying antirheumatic drug therapy persistence between biologics among patients with rheumatoid arthritis (RA) who previously used ≥1 other biologic. METHODS Using a large United States administrative claims dataset, we identified adult patients with RA initiating abatacept, adalimumab, certolizumab, etanercept, golimumab, infliximab, or tocilizumab ...

Introduction An understanding of real-world predictors of abatacept retention is limited. We analysed retention rates and predictors of abatacept retention in biologic-naïve and biologic-failure patients in a 12-month interim analysis of the 2-yearAbataCepTIn rOutiNe clinical practice (ACTION) study. Methods ACTION was an international, observational study of patients with moderate-to-severe ...

BACKGROUND Biologic disease-modifying antirheumatic drugs (DMARDs) are increasingly used for rheumatoid arthritis (RA) treatment. However, little is known based on contemporary data about the factors associated with DMARDs and patterns of use of biologic DMARDs for initial and subsequent RA treatment. METHODS We conducted an observational cohort study using claims data from a commercial healt...

Young children and the developing fetus may be more susceptible to effects of environmental toxicants than adults due to differential exposure patterns and developmental immaturities. Biologic markers offer the potential of quantitative dosimeters of biologic dose and/or indices of biologic effect associated with fetal/childhood exposures. They can facilitate evaluation of interindividual varia...