نتایج جستجو برای: biomarker validation

تعداد نتایج: 227799  

Journal: :JNCI Journal of the National Cancer Institute 2004

Journal: :The American journal of clinical nutrition 2010
Silke S Heinzmann Ian J Brown Queenie Chan Magda Bictash Marc-Emmanuel Dumas Sunil Kochhar Jeremiah Stamler Elaine Holmes Paul Elliott Jeremy K Nicholson

BACKGROUND New food biomarkers are needed to objectively evaluate the effect of diet on health and to check adherence to dietary recommendations and healthy eating patterns. OBJECTIVE We developed a strategy for food biomarker discovery, which combined nutritional intervention with metabolic phenotyping and biomarker validation in a large-scale epidemiologic study. DESIGN We administered a ...

2010
Silke S Heinzmann Ian J Brown Queenie Chan Magda Bictash Marc-Emmanuel Dumas Sunil Kochhar Jeremiah Stamler Elaine Holmes Paul Elliott Jeremy K Nicholson

Background: New food biomarkers are needed to objectively evaluate the effect of diet on health and to check adherence to dietary recommendations and healthy eating patterns. Objective: We developed a strategy for food biomarker discovery, which combined nutritional intervention with metabolic phenotyping and biomarker validation in a large-scale epidemiologic study. Design: We administered a s...

2015
Junwei Tang Runqiu Jiang Lei Deng Xudong Zhang Ke Wang Beicheng Sun

BACKGROUND & AIMS Alpha Fetal Protein (AFP) was one of the traditional biomarker for diagnosis of Hepatocellular carcinoma (HCC) clinically, however, with the low specificity of AFP, the early diagnosis or the metastasis prediction of HCC is inferior. A new, minimally invasive and more specificity biomarker for the diagnosis or metastasis prediction of HCC are necessary. METHODS In this study...

Journal: :Journal of medical genetics 2015
Lauren E Mokry Omar Ahmad Vincenzo Forgetta George Thanassoulis J Brent Richards

Despite increased expenditure, productivity of the pharmaceutical industry has decreased and currently 90% of developed molecules entering phase II and phase III clinical trials fail to gain regulatory approval. Most of these failures are due to lack of therapeutic efficacy rather than lack of safety, suggesting that drug development failures may often be due to poor drug target validation. Cur...

Journal: :Cancer epidemiology, biomarkers & prevention : a publication of the American Association for Cancer Research, cosponsored by the American Society of Preventive Oncology 2010
Zhen Zhang Daniel W Chan

BACKGROUND After more than a decade of biomarker discovery research using advanced genomic and proteomic technologies, very few biomarkers have been translated into clinical diagnostics for patient care. This has become an urgent issue to be addressed because the continuing funding from both the public and private sources are called into question. METHODS We use as an example, OVA1, the first...

Journal: :Briefings in functional genomics & proteomics 2008
Mu Wang Jinsam You Kerry G Bemis Tony J Tegeler Dawn P G Brown

Major technological advances have made proteomics an extremely active field for biomarker discovery and validation in recent years. These improvements have lead to an increased emphasis on larger scale, faster and more efficient methods for protein biomarker discoveries in human tissues, cells and biofluids. However, most current proteomic methodologies for biomarker discovery and validation ar...

2014
Angen Liu

Biomarker is a measurable indicator, such as protein, genetic alteration, or metabolite that found in tissue, blood, or other body fluids. Identification of biomarkers that specifically associated with the particular medical conditions such as cancer, cardiovascular disease and neurological disorder is useful for early detection, prevent, and therapy of the diseases. Availability of biomarkers ...

2014
Esmaeil Atashpaz-Gargari Ulisses Braga-Neto Edward R. Dougherty

BACKGROUND Discovery and validation of protein biomarkers with high specificity is the main challenge of current proteomics studies. Different mass spectrometry models are used as shotgun tools for the discovery of biomarkers. Validation of a set of selected biomarkers from a list of candidates is an important stage in the biomarker identification pipeline. Validation is typically done by tripl...

Journal: :Clinical chemistry 2015
Michael J Duffy Catharine M Sturgeon György Sölétormos Vivian Barak Rafael Molina Daniel F Hayes Eleftherios P Diamandis Patrick M M Bossuyt

BACKGROUND Biomarkers are playing increasingly important roles in the detection and management of patients with cancer. Despite an enormous number of publications on cancer biomarkers, few of these biomarkers are in widespread clinical use. CONTENT In this review, we discuss the key steps in advancing a newly discovered cancer candidate biomarker from pilot studies to clinical application. Fo...

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