نتایج جستجو برای: bioreactor scale
تعداد نتایج: 582284 فیلتر نتایج به سال:
Escherichia coli fed-batch cultivations at 22 m3 scale were compared to corresponding laboratory scale processes and cultivations using a scale-down reactor furnished with a high-glucose concentration zone to mimic the conditions in a feed zone of the large bioreactor. Formate accumulated in the large reactor, indicating the existence of oxygen limitation zones. It is suggested that the reduced...
This case study focuses on the scale-up of a Sp2/0 mouse myeloma cell line based fed-batch bioreactor process, from the initial 3-L bench scale to the 2,500-L scale. A stepwise scale-up strategy that involved several intermediate steps in increasing the bioreactor volume was adopted to minimize the risks associated with scale-up processes. Careful selection of several available mixing models fr...
This thesis focuses on the design and characterisation of miniature bioreactors and evaluates their potential as a scale-down device for microbial cultivation processes. Miniature bioreactors, such as the one detailed in this work, have been developed by many research groups and companies, and seek to increase throughput at the early stages of bioprocess development. Power input was measured in...
In this review, horizontal tubular bioreactors are discussed regarding their advantages and disadvantages compared to other bioreactor types. In horizontal tubular bioreactors medium flow is characterized by plug flow conditions that can be favorable in the case of inhibition and/or repression bioprocess kinetics. For description of liquid flow simple one-parameter or complex multi-parameters m...
As per definition, the bioreactor is the designed space where biological reactions take place. Hence, the bioreactor is essentially an engineering achievement and its design a challenge for bioengineers. The bioreactor should create a biosphere that as profoundly and adequately as possible provides the ideal environment for the biological reaction. The path for reaching, attaining, andmaintaini...
the mixing behavior of the gas-liquid phase in three loop bioreactors was investigated. a gas-induced external airlift loop bioreactor (ealb), a forced-liquid vertical tubular loop bioreactor (vtlb) and a forced-liquid horizontal tubular loop bioreactor (htlb) were used for mixing studies as well as biomass production from natural gas. the effect of design parameters, riser to downcomer cross s...
Mercury-contaminated chemical wastewater of a mercury cell chloralkali plant was cleaned on site by a technical-scale bioremediation system. Microbial mercury reduction of soluble Hg(II) to precipitating Hg(0) decreased the mercury load of the wastewater during its flow through the bioremediation system by up to 99%. The system consisted of a packed-bed bioreactor, where most of the wastewater'...
Widespread use of human umbilical cord cells for cardiovascular tissue engineering requires production of large numbers of well-characterized cells under controlled conditions. In current research projects, the expansion of cells to be used to create a tissue construct is usually performed in static cell culture systems which are, however, often not satisfactory due to limitations in nutrient a...
The key parameters of the inner structure of a cylindrical airlift bioreactor, including the ratio of the cross-section area of the downcomer to the cross-section area of the riser, clearance from the upper edge of the draft tube to the water level, and clearance from the low edge of the draft tube to the bottom of the reactor, significantly affected the biomass production of Botryococcus braun...
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