taxol is used to treatment of variety cancers including ovarian, breast, lung, head and neck carcinomas and the aids-related karposi’s carcinoma, and was originally obtained from bark of taxus brevifolia. however the amount of extracted taxol from taxus is extremely low and cannot be considered as a suitable commercial source and it has led to studies for finding new sources of taxol. in 1998, ...

The effect of combination of ketoconazole with other sterol synthesis inhibitors on fungal growth was tested against a variety of fungi selected for resistance to ketoconazole. All of the sterol inhibitors, at concentrations lower than their MICs, caused an increase greater than fourfold in the ketoconazole susceptibility of some fungi. Some of the sterol synthesis inhibitors showed this effect...

Thermus thermophilus biosynthesizes lysine through the α-aminoadipate (AAA) pathway: this observation was the first discovery of lysine biosynthesis through the AAA pathway in archaea and bacteria. Genes homologous to the T. thermophilus lysine biosynthetic genes are widely distributed in bacteria of the Deinococcus-Thermus phylum. Our phylogenetic analyses strongly suggest that a common ancest...

Abstract Investigating metabolic rewiring in cancer can lead to the discovery of new treatment strategies for breast subtypes that currently lack targeted therapies. In this study, we used MMTV-Myc–driven tumors model heterogeneity, investigating differences between two histologic subtypes, epithelial–mesenchymal transition (EMT) and papillary subtypes. A combination genomic metabolomic techniq...

27 There is increasing evidence that endoplasmic reticulum (ER) stress contributes to the 28 development atherosclerosis in diabetes mellitus. The purpose of this study was to determine the effects 29 of increased hexosamine biosynthesis pathway (HBP) flux on ER stress levels and the complications of 30 ER stress associated with diabetes and atherosclerosis in hepatic cells. Glutamine:fructose-...

Temperate woody plants suffer environmental stresses caused by seasonal changes. Seasonal changes affect tree cambium activity, resulting in the annual periodicity of growth. In present study, we provide a model for plant hormone coordination monolignol biosynthesis to cope with poplar species. First, 27 core lignin-related genes were identified Populus tomentosa, and co-expression lignifying t...

Valeriana officinalis (valerian), as a nutraceutical herb, is widely used for its sedative and hypnotic properties. It is known that C15 sesquiterpenoid valerenic acid (VA) is the active ingredient responsible for pharmacological effects of V. officinalis. To evaluate the effect of methyl jasmonate (MeJA) concentrations (50 and 100 µM...

Terpenoids are a large class of lipid molecules with important biological functions and diverse industrial medicinal applications. Metabolic engineering for terpene production has been hindered by the low-flux distribution to its biosynthesis pathway.