OBJECTIVES Bipolar disorder is accompanied by cognitive impairments, which persists during euthymic phases. The purpose of the present study was to identify those neuropsychological tests that most reliably tell euthymic bipolar patients and controls apart, and to clarify the extent to which these cognitive impairments are clinically significant as judged from neuropsychological norms. METHOD...

OBJECTIVE Emerging evidence suggests that inflammation and neurodegeneration underlies bipolar disorder. To investigate biological markers of cytokines and brain-derived neurotrophic factor between bipolar I, bipolar II, and other specified bipolar disorder with short duration hypomania may support the association with inflammatory dysregulation and bipolar disorder and, more specifically, prov...

BACKGROUND Psychiatric phenotypes are currently defined according to sets of descriptive criteria. Although many of these phenotypes are heritable, it would be useful to know whether any of the various diagnostic categories in current use identify cases that are particularly helpful for biological-genetic research. AIMS To use genome-wide genetic association data to explore the relative genet...

objective: patients with bipolar mood disorder constitute a relatively large number of individuals hospitalized in psychiatric hospitals. this disorder is highly co-morbid with other psychiatric disorders and may effect their clinical course. the goal of this study was to determine the co-occurrence rate of anxiety disorders and substance abuse with bipolar mood disorders and their impact on cl...

background : the existing evidence about the clinical situations of the bipolar patients with opioid dependence is scarce. the present study was carried out to compare the clinical features and course of the bipolar disorder type i regarding the two subgroups of opioid dependent and non-dependent. methods : there were 178 adult patients with bipolar disorder type i consecutively referred to the...

Methods 130 patients (17 with major depressive disorder (UP), 67 with major depressive episode in bipolar disorder type II (BP II), 46 with major depressive episode in bipolar disorder type I (BP I) and 50 with mixed state (MS) according to the DSM-IV criteria) were included in the study and treated with bilateral ECT, on a twice-a-week schedule. The patients were assessed before (baseline) and...

CONTEXT Affective disorders are common in women, with many episodes having an onset in pregnancy or during the postpartum period. OBJECTIVE To investigate the occurrence and timing of perinatal mood episodes in women with bipolar I disorder, bipolar II disorder, and recurrent major depression (RMD). SETTING AND PATIENTS Women were recruited in our ongoing research on the genetic and nongenetic ...

J Clin Psychiatry 2015;76(2):e222–e223 (doi:10.4088/JCP.14com09639). © Copyright 2015 Physicians Postgraduate Press, Inc. O 40 years ago, clinical observations generated proposals for a distinction among mood-disordered patients between those who experience mania in the course of their illness and those who experience only hypomania.1 Concerns that this distinction could not be made reliably de...

BACKGROUND This study aimed to identify susceptible loci and enriched pathways for bipolar disorder subtype II. METHODS We conducted a genome-wide association scan in discovery samples with 189 bipolar disorder subtype II patients and 1773 controls, and replication samples with 283 bipolar disorder subtype II patients and 500 controls in a Taiwanese Han population using Affymetrix Axiom Genom...

Sir: Bipolar II disorder is a valid and reliable diagnosis and its prevalence in society is higher than was once assumed. Considering the fact that the main clinical presentation of bipolar II disorder is composed of depressive symptoms and the fact that the retrospective diagnosis of episodes of hypomania is often difficult, there has been an increased concern about the underdiagnosis of bipol...