Multiple observations point to involvement of lipid membrane domains, known as lipid rafts, in the pathology of human disorders. The putative role of lipid rafts in hereditary and acquired skin blistering diseases is discussed in this review. Stable adhesion of the epidermis to the underlying basement membrane is secured by hemidesmosomes, specialized multiprotein complexes in basal keratinocyt...

Epidermolysis bullosa acquisita (EBA) is an autoimmune subepidermal blistering disease of mucous membranes and the skin caused by autoantibodies against collagen VII. In silico and wet laboratory epitope mapping studies revealed numerous distinct epitopes recognized by EBA patients' autoantibodies within the non-collagenous (NC)1 and NC2 domains of collagen VII. However, the distribution of pat...

Background Postoperative pyoderma gangrenosum (PPG) is a rare inflammatory skin disease of unknown etiology characterized by blistering and ulcerative lesions in postoperative wounds. Untreated (PG) potentially life-threatening; therefore, immediate appropriate treatment essential. Although PPG surgical site infection (SSI) present similar clinical findings, they should be differentiated becaus...

There is a well-known shortage of racial diversity in medical textbooks and literature contributing to race-based health care inequalities1. We present the case black puertorrican 58-year-old female who developed painful non-pruritic blistering ulcer inner oral mucosa with associated erythema six months prior evaluation. She was misdiagnosed on multiple occasions leading rapid progression disea...

BACKGROUND/PURPOSE Friction blisters, a common injury in sports and military operations, can adversely effect or even halt performance. Given its frequency and hazardous nature, recent research efforts appear limited. Blistering can be treated as a delamination phenomenon; similar issues in materials science have been extensively investigated in theory and experiment. An obstacle in studying bl...

299 How to cite this article: Abreu Velez AM, Jackson BL, Howard MS. Intraepidermal and subepidermal blistering with skin necrosis, possibly caused by etanercept in treatment of a patient with psoriasis. Our Dermatol Online. 2015;6(3):299-303. Submission: 22.01.2015; Acceptance: 12.03.2015 DOI:10.7241/ourd.20153.80 Intraepidermal and subepidermal blistering with skin necrosis, possibly caused b...

background: pemphigus vulgaris is a life threatening, blistering skin disease. it is an autoimmune abnormality. due to involvement of oral cavity and pharynx, patients are at risk of nutrients deficiency. the aim of this study was to evaluate the status of selenium, copper, and zinc in these patients. methods: in a case-control study, 43 newly diagnosed pemphigus vulgaris patients were compared...

Objective: As a rare autoimmune disease, pemphigus vulgaris has a poor prognosis especially in lack of proper medical support. This blistering disease involves both the skin and mucus membranes. The challenge is improving the healing process of skin lesions of which, superimposed infections are among the main causes of the disease mortality. Accordingly, we aimed to assess the treatment options...