We focus on tandem queues with subexponential service time distributions. We assume that number of customers in front of the first station is infinite and there is infinite room for finished customers after the last station but the size of the buffer between two consecutive stations is finite. Using (max,+) linear recursions, we investigate the tail asymptotics of transient response times and w...

Early Synovectomy is advisable for rheum­atoid arthritis. An autologus vaccine from the excised synovia can be prepared from the tis-­ sues and given to the patient for at least 2 years or even longer in order to arrest the di­sease and for prevent relapse.  The patient can be taught to give himself his own vaccine two times weekly. While there is possibility of an antianaphylactic reaction. F...

As multi-factory production models are more widespread in modern manufacturing systems, a distributed blocking flowshop scheduling problem (DBFSP) is studied which no buffer between adjacent machines and setup time constraints considered. To address the above problem, mixed integer linear programming (MILP) model first constructed, its correctness verified. Then, an iterated greedy-algorithm-bl...

In this paper it is presented an improvement of the branch and bound algorithm for permutation flow shop problem with blocking-in-process setup times objective minimizing total time tardiness, which known to be NP-Hard when there are two or more machines involved. With that in mind, a new machine-based lower exploits some structural properties problem. A database 27 classes problems, varying nu...

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The uptake of guanethidine (3.3×10-5 M), debrisoquin (8.4×10-4 M), bretyliun (5.0 10-4 M) and xylocholine (1.0×10-3 M) by adrenergic neuron was studied indirectly by testing the ability of noradrenaline (NA) regarding low temp. or sodium deprivation to prevent or reverse adrenergic neuron blocking action in the indirectly stimulated ...

AIMS Haemostasis interrupts bleeding from disrupted blood vessels by activating platelet aggregation and coagulation. A similar mechanism termed thrombosis generates obstructive thrombi inside diseased arteries. As a consequence of this similarity, current anti-thrombotic agents increase the risk of bleeding. Atherosclerotic plaques produce significant amounts of prostaglandin E2 (PGE2), which ...

As supercomputers become faster, the I/O part of applications can become a real problem in regard to overall execution times. System administrators and developers of hardware or software components reduce execution times by creating new and optimized parts for the supercomputers. While this helps a lot in the struggle to minimize I/O times, adjustment of the execution environment is not the onl...

Previous studies have shown that symmetric tetraalkylammonium ions affect, in a voltage-dependent manner, the conductance of membranes containing many channels formed by the PA65 fragment of anthrax toxin. In this paper we analyze this phenomenon at the single-channel level for tetrabutylammonium ion (Bu4N+). We find that Bu4N+ induces a flickery block of the PA65 channel when present on either...

Whole-cell High-Throughput Screening (HTS) is a key tool for the discovery of much needed malaria transmission blocking drugs. Discrepancies in the reported outcomes from various HTS Plasmodium falciparum gametocytocidal assays hinder the direct comparison of data and ultimately the interpretation of the transmission blocking potential of hits. To dissect the underlying determinants of such dis...